药品评价
藥品評價
약품평개
Drug Evaluation
2015年
14期
28-32
,共5页
血管新生素%受体Tie2%白血病
血管新生素%受體Tie2%白血病
혈관신생소%수체Tie2%백혈병
angiogenesis%Tie2%leukemia
血管生成素及其受体Tie2是近年来发现的血管生成调节因子,在肿瘤血管新生中具有促进血管稳定、成熟和重建的作用.最新研究证实,血管生成素及其受体Tie2在白血病中异常表达,与白血病的细胞形态、免疫分型、核型及预后等因素相关,并且在白血病的治疗中发挥着重要的作用,对白血病的预后也有一定的意义.由此表明,研究血管生成素及其受体Tie2在白血病中的表达及其病理生理机制,将有利于白血病治疗的进展.现结合相关参考文献与临床试验对血管生成素及其受体Tie2在白血病中的研究现状进行如下综述.
血管生成素及其受體Tie2是近年來髮現的血管生成調節因子,在腫瘤血管新生中具有促進血管穩定、成熟和重建的作用.最新研究證實,血管生成素及其受體Tie2在白血病中異常錶達,與白血病的細胞形態、免疫分型、覈型及預後等因素相關,併且在白血病的治療中髮揮著重要的作用,對白血病的預後也有一定的意義.由此錶明,研究血管生成素及其受體Tie2在白血病中的錶達及其病理生理機製,將有利于白血病治療的進展.現結閤相關參攷文獻與臨床試驗對血管生成素及其受體Tie2在白血病中的研究現狀進行如下綜述.
혈관생성소급기수체Tie2시근년래발현적혈관생성조절인자,재종류혈관신생중구유촉진혈관은정、성숙화중건적작용.최신연구증실,혈관생성소급기수체Tie2재백혈병중이상표체,여백혈병적세포형태、면역분형、핵형급예후등인소상관,병차재백혈병적치료중발휘착중요적작용,대백혈병적예후야유일정적의의.유차표명,연구혈관생성소급기수체Tie2재백혈병중적표체급기병리생리궤제,장유리우백혈병치료적진전.현결합상관삼고문헌여림상시험대혈관생성소급기수체Tie2재백혈병중적연구현상진행여하종술.
Angiogenesis and its receptor Tie2 is a regulator of angiogenesis in recent years. It has the effect of promoting blood vessel stability, maturation and reconstruction in tumor angiogenesis. Recent studies have demonstrated that the expression of Tie2 in leukemia is associated with the abnormal expression of leukemia cells, which is associated with the cell morphology, immune typing and prognosis, and plays an important role in the treatment of leukemia. It is indicated that the expression of Tie2 in leukemia and its pathophysiological mechanism will be beneficial to the development of leukemia treatment. This paper reviews the current research status of Tie2 in leukemia by combining the relevant references and clinical trials.
