CAJ | 학술논문

背景：腰椎管狭窄引起腰椎两侧神经根痛等不适症状甚至致残，严重影响人们的生活质量，针对这种疾病临床上主要采用椎间融合治疗。有研究表明棘突融合器易出现骨裂及植入器脱落等现象，所以实验从腰椎 L4/5棘突研究椎间融合器的生物力学特性和生物相容性。 　　目的：分析研究腰椎L4/5棘突间植入椎间融合器的稳定性，以及对相邻节段的生物力学特性和生物相容性。 　　方法：选择10组新鲜的成人冰冻脊柱标本，将10个标本分为2组，分别为正常标本组和模拟腰椎棘突间植入物组，每组5例。对标本进行编号并放置固定在特殊的夹具中，使用由郑州凯斯特医疗器械有限公司生产的腰椎融合器，选择棘突间弹性内植入，由Ti6AL-4V ELI钛合金构成的cage固定器固定。 　　结果与结论：人工椎体不同植入位置在中心压缩、前屈、后伸、侧屈4种状态下的应变变化均小于正常组标本(P <0.05)。两组标本在最大载荷500 N下椎体的位移数据中，与正常标本组比较，模拟腰椎棘突间植入物组线性位移和角位移在前屈、后伸、左侧屈、左旋转时均减小(P <0.05)。结果表明，腰椎棘突间融合器能够保留伤椎的大部分活动度，维持节段稳定性，降低椎间盘应力。
배경：요추관협착인기요추량측신경근통등불괄증상심지치잔，엄중영향인문적생활질량，침대저충질병림상상주요채용추간융합치료。유연구표명극돌융합기역출현골렬급식입기탈락등현상，소이실험종요추 L4/5극돌연구추간융합기적생물역학특성화생물상용성。 　　목적：분석연구요추L4/5극돌간식입추간융합기적은정성，이급대상린절단적생물역학특성화생물상용성。 　　방법：선택10조신선적성인빙동척주표본，장10개표본분위2조，분별위정상표본조화모의요추극돌간식입물조，매조5례。대표본진행편호병방치고정재특수적협구중，사용유정주개사특의료기계유한공사생산적요추융합기，선택극돌간탄성내식입，유Ti6AL-4V ELI태합금구성적cage고정기고정。 　　결과여결론：인공추체불동식입위치재중심압축、전굴、후신、측굴4충상태하적응변변화균소우정상조표본(P <0.05)。량조표본재최대재하500 N하추체적위이수거중，여정상표본조비교，모의요추극돌간식입물조선성위이화각위이재전굴、후신、좌측굴、좌선전시균감소(P <0.05)。결과표명，요추극돌간융합기능구보류상추적대부분활동도，유지절단은정성，강저추간반응력。
BACKGROUND:Lumbar spinal stenosis can result in lumbar nerve root pain and other symptoms or even disability, which seriously impacts people’s quality of life. Interbody fusion is the main clinical treatment. Studies have shown that an interspinous fusion cage is prone to have hairline fractures and loss of implant; therefore, biomechanical properties and biocompatibility of the interbody fusion cage at L4/5need to be studied. OBJECTIVE:To analyze the stability of the interspinous fusion cage at L4/5, and to explore the biomechanical properties and biocompatibility of adjacent segments. METHODS: Ten adult fresh frozen spine specimens were selected and divided into normal group and model group, with five specimens in each group. The specimens were numbered and placed in a special fixture. The interspinous fusion cage, made in Zhengzhou Cast Medical Instrument Co., Ltd., China, was implantedin vivo and fixed using a cage fixator made of Ti6AL-4V ELI. RESULTS AND CONCLUSION:Artificial vertebral bodies had less strain changes than the normal vertebrae in different implantation positions in terms of central compression, anteflexion, rear protraction, lateroflexion (P < 0.05). During vertebral displacement under the maximum load of 500 N, the linear displacement and angular displacement in anteflexion, rear protraction, left lateral flexion, levorotation were decreased significantly in the model group than the normal group (P < 0.05). These findings indicate that the interspinous fusion cage can maximaly preserve the range of motion of the injured vertebral body, maintain the stability of the segment, and reduce the stress of the intervertebral disc.