CAJ | 학술논문

治疗性低温能改善心脏停搏患者全脑缺血缺氧损伤后神经功能转归。治疗性低温也是研究最广泛和具有影响力的急性缺血性卒中治疗策略之一。既往的治疗性低温研究主要集中于全身低温，但诱导速度慢和全身并发症等限制了其临床应用。作为选择性脑低温的一种，选择性动脉内脑低温治疗具有诱导快速、降温均匀及较少影响核心体温的特点，因此成为一种有希望的治疗方式。文章综述了选择性动脉内脑低温在急性缺血性卒中的应用及其优势和局限性，为更深入的实验研究和未来的临床试验提供参考。
치료성저온능개선심장정박환자전뇌결혈결양손상후신경공능전귀。치료성저온야시연구최엄범화구유영향력적급성결혈성졸중치료책략지일。기왕적치료성저온연구주요집중우전신저온，단유도속도만화전신병발증등한제료기림상응용。작위선택성뇌저온적일충，선택성동맥내뇌저온치료구유유도쾌속、강온균균급교소영향핵심체온적특점，인차성위일충유희망적치료방식。문장종술료선택성동맥내뇌저온재급성결혈성졸중적응용급기우세화국한성，위경심입적실험연구화미래적림상시험제공삼고。
Therapeutic hypothermia has been shown to improve neurological outcomes after global ischaemia/hypoxia in patients who have had cardiac arrest. Therapeutic hypothermia is one of the most extensively studied and influential therapeutic strategies of acute ischemic stroke. Previous studies of therapeutic hypothermia mainly focused on whole-body cooling. However, delayed induction and systemic complications have limited the clinical application of whole-body cooling. As a selective cerebral hypothermia, the selective intra-arterial brain hypothermia treatment has the characteristics of rapid and even induction of hypothermia, and less affecting the core body temperature. Therefore, it has become a promising treatment modality. This article reviews the application of selective intra-arterial brain hypothermia in acute ischemic stroke and its advantages and limitations in order to provide reference for further experimental studies and future clinical trials.