国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
International Journal of Cerebrovascular Diseases
2015年
9期
710-714
,共5页
脑小血管疾病%生物学标记%内皮,血管%血脑屏障%炎症%淀粉样 β 蛋白肽
腦小血管疾病%生物學標記%內皮,血管%血腦屏障%炎癥%澱粉樣 β 蛋白肽
뇌소혈관질병%생물학표기%내피,혈관%혈뇌병장%염증%정분양 β 단백태
Cerebral Smal Vessel Diseases%Biological Markers%Endothelium,Vascular%Blood-Brain Barrier%Inflammation%Amyloid β-Peptides
脑小血管病(cerebral smal vessel disease, CSVD)是指脑小穿支动脉和小动脉(直径40~200μm)、毛细血管及小静脉的各种病变所导致的临床、认知和病理学表现的综合征,其影像学分型包括腔隙性梗死、脑白质病变、脑微出血、血管周围间隙扩大等。 CSVD 的发病机制仍在探索之中,并且影像学表现不能完整体现其病理生理学变化过程,尤其是早期病变,因此给 CSVD 的防治增加了困难。文章对 CSVD 生物学标记物的研究进展进行了综述,以期为其病因、发病机制和临床防治提供思路。
腦小血管病(cerebral smal vessel disease, CSVD)是指腦小穿支動脈和小動脈(直徑40~200μm)、毛細血管及小靜脈的各種病變所導緻的臨床、認知和病理學錶現的綜閤徵,其影像學分型包括腔隙性梗死、腦白質病變、腦微齣血、血管週圍間隙擴大等。 CSVD 的髮病機製仍在探索之中,併且影像學錶現不能完整體現其病理生理學變化過程,尤其是早期病變,因此給 CSVD 的防治增加瞭睏難。文章對 CSVD 生物學標記物的研究進展進行瞭綜述,以期為其病因、髮病機製和臨床防治提供思路。
뇌소혈관병(cerebral smal vessel disease, CSVD)시지뇌소천지동맥화소동맥(직경40~200μm)、모세혈관급소정맥적각충병변소도치적림상、인지화병이학표현적종합정,기영상학분형포괄강극성경사、뇌백질병변、뇌미출혈、혈관주위간극확대등。 CSVD 적발병궤제잉재탐색지중,병차영상학표현불능완정체현기병리생이학변화과정,우기시조기병변,인차급 CSVD 적방치증가료곤난。문장대 CSVD 생물학표기물적연구진전진행료종술,이기위기병인、발병궤제화림상방치제공사로。
Cerebral smal vessel disease (CSVD) refers to cerebral smal perforating arteries and arterioles (diameter 40 - 200 μm), capilaries, and venules caused syndromes of clinical, cognitive and pathological manifestations. Its imaging classification includes lacunar infarcts, white matter lesions, cerebral microbleed, and perivascular space enlargement, etc. The pathogenesis of CSVD is stil being explored, and imaging findings can not completely reflect the change process of its pathophysiology, especialy the early lesions. Therefore, the difficulties have increased for the prevention and treatment of CSVD. This article summarizes the progress in research on CSVD biomarkers in recent years in order to provide ideas for its etiology, pathogenesis, and clinical prevention and treatment.
