国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
International Journal of Biologicals
2015年
5期
254-256
,共3页
T淋巴细胞,调节%T淋巴细胞亚群%自身免疫疾病
T淋巴細胞,調節%T淋巴細胞亞群%自身免疫疾病
T림파세포,조절%T림파세포아군%자신면역질병
T-lymphocytes regulatory%T-lymphocyte subsets%Autoimmune diseases
滤泡调节性T细胞(follicular regulatory T cell,Tfr)是一类新发现的调节性T细胞亚群,其特点是表面表型与滤泡辅助性T细胞(T follicular helper cell,Tfh)和效应调节性T细胞(regulatory T cell,Treg)细胞均有重叠,因此,Tfr在功能上具有Tfh和Treg的双重特性.近年来,Tfr在原发性免疫性血小板减少、重症肌无力、强直性脊柱炎和多发性硬化等自身免疫病中的研究得到了广泛关注,此文对Tfr及其在自身免疫病中的研究进展做一概述.
濾泡調節性T細胞(follicular regulatory T cell,Tfr)是一類新髮現的調節性T細胞亞群,其特點是錶麵錶型與濾泡輔助性T細胞(T follicular helper cell,Tfh)和效應調節性T細胞(regulatory T cell,Treg)細胞均有重疊,因此,Tfr在功能上具有Tfh和Treg的雙重特性.近年來,Tfr在原髮性免疫性血小闆減少、重癥肌無力、彊直性脊柱炎和多髮性硬化等自身免疫病中的研究得到瞭廣汎關註,此文對Tfr及其在自身免疫病中的研究進展做一概述.
려포조절성T세포(follicular regulatory T cell,Tfr)시일류신발현적조절성T세포아군,기특점시표면표형여려포보조성T세포(T follicular helper cell,Tfh)화효응조절성T세포(regulatory T cell,Treg)세포균유중첩,인차,Tfr재공능상구유Tfh화Treg적쌍중특성.근년래,Tfr재원발성면역성혈소판감소、중증기무력、강직성척주염화다발성경화등자신면역병중적연구득도료엄범관주,차문대Tfr급기재자신면역병중적연구진전주일개술.
Follicular regulatory T cells (Tfr) is a newly discovered regulatory T cell subset, with the dual characteristics of T follicular helper cell and regulatory T cell.Recent studies on Tfr involved in diseases, including primary immune thrombocytopenia, myasthenia gravis, ankylosing spondylitis, multiple sclerosis, have drawn wide attention.Herein, research advance of Tfr and its potential role in diseases is reviewed.
