国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
International Journal of Biologicals
2015年
5期
213-216
,共4页
李伟%牟蕾%鲁涛%王黔川%余伟
李偉%牟蕾%魯濤%王黔川%餘偉
리위%모뢰%로도%왕검천%여위
因子Ⅷ%溶血%血管刺激性
因子Ⅷ%溶血%血管刺激性
인자Ⅷ%용혈%혈관자격성
Factor Ⅷ%Hemolysis%Vascular irritation
目的 评估人凝血因子Ⅷ(human coagulation factorⅧ,hFⅧ)的溶血性和血管刺激性.方法 以家兔为实验动物,对hFⅧ进行体外溶血和体内血管刺激性实验.结果 在3h体外实验期间未观察到兔红细胞发生溶血和凝聚.当以40 IU/kg剂量的hFⅧ对家兔进行静脉注射时,未观察到家兔耳缘静脉的血管刺激性反应.结论 静脉注射推荐剂量的hFⅧ不会发生溶血和血管刺激反应.
目的 評估人凝血因子Ⅷ(human coagulation factorⅧ,hFⅧ)的溶血性和血管刺激性.方法 以傢兔為實驗動物,對hFⅧ進行體外溶血和體內血管刺激性實驗.結果 在3h體外實驗期間未觀察到兔紅細胞髮生溶血和凝聚.噹以40 IU/kg劑量的hFⅧ對傢兔進行靜脈註射時,未觀察到傢兔耳緣靜脈的血管刺激性反應.結論 靜脈註射推薦劑量的hFⅧ不會髮生溶血和血管刺激反應.
목적 평고인응혈인자Ⅷ(human coagulation factorⅧ,hFⅧ)적용혈성화혈관자격성.방법 이가토위실험동물,대hFⅧ진행체외용혈화체내혈관자격성실험.결과 재3h체외실험기간미관찰도토홍세포발생용혈화응취.당이40 IU/kg제량적hFⅧ대가토진행정맥주사시,미관찰도가토이연정맥적혈관자격성반응.결론 정맥주사추천제량적hFⅧ불회발생용혈화혈관자격반응.
Objective To evaluate hemolysis and vascular irritation of human coagulation factor Ⅷ (hFⅧ).Methods Using rabbits as experimental animals, hemolysis and vascular irritation of hFⅧ were studied by in vitro and in vivo tests.Results Hemolysis and agglutination of rabbit erythrocytes were not observed during the in vitro test within 3 h.The vascular irritation reaction of ear vein was not observed with intravenous administration of hFⅧ at 40 IU/kg.Conclusion There is no hemolysis or vascular irritation with intravenous administration of hFⅧ at recommended dosage.
