山东医药
山東醫藥
산동의약
Shandong Medical Journal
2015年
41期
1-3
,共3页
冠状动脉疾病%急性冠脉综合征%血小板源性生长因子%血管内超声
冠狀動脈疾病%急性冠脈綜閤徵%血小闆源性生長因子%血管內超聲
관상동맥질병%급성관맥종합정%혈소판원성생장인자%혈관내초성
coronary disease%acute coronary syndrome%platelet-derived growth factor%intravascular ultrasound
目的 探讨不同类型冠心病患者血清血小板源性生长因子( PDGF)表达及其与斑块超声显像特征的相关性. 方法 选取冠状动脉(冠脉)造影检查患者138 例,其中急性冠脉综合征( ACS) 65 例[不稳定型心绞痛(UAP)组35例,急性心肌梗死(AMI)组30例],非急性冠脉综合征73例[稳定型心绞痛(SAP)组40例,陈旧性心肌梗死( OMI)组18例] ,冠脉造影正常者15例(对照组). 采用双抗体夹心酶联免疫吸附法检测各组血清PDGF水平,采用血管内超声检查ACS组和SAP组患者冠脉病变情况,比较不同性质斑块患者血清PDGF水平的差异.结果 SAP、OMI、UAP、AMI组血清PDGF浓度均高于对照组(P均<0.05);UAP、AMI组血清PDGF浓度高于SAP、OMI组(P均<0.05);AMI组血清PDGF浓度高于UAP组(P<0.05). SAP组冠脉病变以硬斑块为主,ACS组以软斑块为主;ACS组斑块破裂、血栓形成、正性重构发生率高于SAP组(P均<0.05),SAP组与ACS组偏心指数比较差异有统计学意义(P<0.05). 纤维斑块、钙化斑块、混合斑块患者血清PDGF浓度均低于软斑块患者(P均<0.05).结论 PDGF参与冠脉粥样硬化斑块的形成,血清PDGF水平检测可为临床诊断、预防和治疗ACS提供新的思路.
目的 探討不同類型冠心病患者血清血小闆源性生長因子( PDGF)錶達及其與斑塊超聲顯像特徵的相關性. 方法 選取冠狀動脈(冠脈)造影檢查患者138 例,其中急性冠脈綜閤徵( ACS) 65 例[不穩定型心絞痛(UAP)組35例,急性心肌梗死(AMI)組30例],非急性冠脈綜閤徵73例[穩定型心絞痛(SAP)組40例,陳舊性心肌梗死( OMI)組18例] ,冠脈造影正常者15例(對照組). 採用雙抗體夾心酶聯免疫吸附法檢測各組血清PDGF水平,採用血管內超聲檢查ACS組和SAP組患者冠脈病變情況,比較不同性質斑塊患者血清PDGF水平的差異.結果 SAP、OMI、UAP、AMI組血清PDGF濃度均高于對照組(P均<0.05);UAP、AMI組血清PDGF濃度高于SAP、OMI組(P均<0.05);AMI組血清PDGF濃度高于UAP組(P<0.05). SAP組冠脈病變以硬斑塊為主,ACS組以軟斑塊為主;ACS組斑塊破裂、血栓形成、正性重構髮生率高于SAP組(P均<0.05),SAP組與ACS組偏心指數比較差異有統計學意義(P<0.05). 纖維斑塊、鈣化斑塊、混閤斑塊患者血清PDGF濃度均低于軟斑塊患者(P均<0.05).結論 PDGF參與冠脈粥樣硬化斑塊的形成,血清PDGF水平檢測可為臨床診斷、預防和治療ACS提供新的思路.
목적 탐토불동류형관심병환자혈청혈소판원성생장인자( PDGF)표체급기여반괴초성현상특정적상관성. 방법 선취관상동맥(관맥)조영검사환자138 례,기중급성관맥종합정( ACS) 65 례[불은정형심교통(UAP)조35례,급성심기경사(AMI)조30례],비급성관맥종합정73례[은정형심교통(SAP)조40례,진구성심기경사( OMI)조18례] ,관맥조영정상자15례(대조조). 채용쌍항체협심매련면역흡부법검측각조혈청PDGF수평,채용혈관내초성검사ACS조화SAP조환자관맥병변정황,비교불동성질반괴환자혈청PDGF수평적차이.결과 SAP、OMI、UAP、AMI조혈청PDGF농도균고우대조조(P균<0.05);UAP、AMI조혈청PDGF농도고우SAP、OMI조(P균<0.05);AMI조혈청PDGF농도고우UAP조(P<0.05). SAP조관맥병변이경반괴위주,ACS조이연반괴위주;ACS조반괴파렬、혈전형성、정성중구발생솔고우SAP조(P균<0.05),SAP조여ACS조편심지수비교차이유통계학의의(P<0.05). 섬유반괴、개화반괴、혼합반괴환자혈청PDGF농도균저우연반괴환자(P균<0.05).결론 PDGF삼여관맥죽양경화반괴적형성,혈청PDGF수평검측가위림상진단、예방화치료ACS제공신적사로.
Objective To explore the expression of platelet-derived growth factor ( PDGF) in patients with different types of coronary heart disease and its correlation with the characteristics of ultrasound imaging of plaque.Methods We selected 138 cases of patients with coronary angiography, including 65 patients with acute coronary syndrome (ACS), 35 patients with unstable angina ( UAP) and 30 patients with acute myocardial infarction ( AMI) , 73 patients with non-acute coronary syndrome, including 40 patients with stable angina ( SAP) and 18 patients with old myocardial infarction ( OMI) , and 15 patients with normal coronary angiography.Using double antibody sandwich enzyme-linked immunosorbent method to detect serum level of PDGF in patients.Using intravascular ultrasound was used to detect the coronary lesions of patients with ACS and SAP, and we compared the differences in the levels of serum PDGF in different plaques of patients.Results The serum PDGF concentrations in the SAP, OMI, UAP and AMI patients were higher than those of the control group (all P<0.05), the serum PDGF concentrations of the UAP and AMI patients were higher than those of the SAP and OMI patients (all P<0.05);the serum PDGF concentration of AMI patients was higher than the UAP patients (P<0.05). The coronary lesions in the SAP group were mainly hard plaques, and those of the ACS group were mainly soft plaques.The occurrence rates of ACS plaque rupture, thrombosis and positive remodeling were higher than those of SAP (all P<0.05), and the difference between SAP and ACS was statistically significant (P<0.05).The average level of PDGF in patients with fibrous plaque, calcified plaque and mixed plaque was lower than that of patients with soft plaque (all P<0.05). Conclusions PDGF is involved in the formation of coronary atherosclerotic plaque, and serum PDGF level can provide a new way for clinical diagnosis, prevention and treatment of ACS.
