CAJ | 학술논문

以聚乙二醇400(PEG-400)作溶剂,通过 CuSO 4/KI 催化的邻氨基吡啶与苯乙酮的串联式缩合-环化-芳构化反应,发展出一种高效且环境友好型的合成2-苯基咪唑并[1,2-a]吡啶的方法。该方法具有操作简单、使用无毒性 PEG-400作反应介质、催化剂安全价廉等优点。所有产物结构经1 H NMR 及13 C NMR 进行了确认。
이취을이순400(PEG-400)작용제,통과 CuSO 4/KI 최화적린안기필정여분을동적천련식축합-배화-방구화반응,발전출일충고효차배경우호형적합성2-분기미서병[1,2-a]필정적방법。해방법구유조작간단、사용무독성 PEG-400작반응개질、최화제안전개렴등우점。소유산물결구경1 H NMR 급13 C NMR 진행료학인。
An environmentally friendly method has been developed for efficient synthesis of 2-phenyl-imi-dazo [1,2-a]pyridines via CuSO 4/KI catalyzed condensation-cyclization-aromatixation cascade reation of o-aminopyridine with acetophenone in polythylene glycol 400 (PEG-400).This method exhibited the ad-vatages of simple operation,use of nontoxic PEG-400 as the reaction medium,employing safe and cheap catalyst.The structures of all products were confimed by 1 H NMR and 1 3 C NMR.