CAJ | 학술논문

自噬是细胞对不良环境的一种自我防御机制,真核细胞通过自噬清除异常积聚的蛋白和损伤的或多余的细胞器,甚至病原微生物来维持细胞内稳态.近年来的研究表明,自噬与众多眼病包括白内障、角膜营养不良、青光眼、年龄相关性黄斑病变等疾病的发生和发展有着密切联系.期望通过小分子化合物(自噬的激活剂或抑制剂)或者药物调控细胞的自噬水平,从而为眼部疾病提供一种新的治疗策略.
자서시세포대불량배경적일충자아방어궤제,진핵세포통과자서청제이상적취적단백화손상적혹다여적세포기,심지병원미생물래유지세포내은태.근년래적연구표명,자서여음다안병포괄백내장、각막영양불량、청광안、년령상관성황반병변등질병적발생화발전유착밀절련계.기망통과소분자화합물(자서적격활제혹억제제)혹자약물조공세포적자서수평,종이위안부질병제공일충신적치료책략.
Autophagy is a kind of cell status with which cells can protect themselves from unfavorable micro-environment.Eukaryotic cells clear accumulation of abnormal proteins, damaged or redundant organelles and microorganisms by autophagy to maintain cellular homeostasis.Increasing evidences had shown that autophagy is closely associated with the pathogenesis and progression of a number of ocular disorders including cataract, corneal dystrophy, glaucoma, age-related macular degeneration and other eye diseases.We expect regulating cell autophagy by small molecular compound (activator or depressor of autophagy) or durg, which will provide new treatment strategies for eye diseases.