国际眼科纵览
國際眼科縱覽
국제안과종람
International Review of Ophthalmology
2015年
5期
327-332
,共6页
年龄相关性黄斑变性%细胞因子
年齡相關性黃斑變性%細胞因子
년령상관성황반변성%세포인자
age-related macular degeneration%cytokines
年龄相关性黄斑变性(age-related macular degeneration,AMD),是发达国家50岁以上人群常见的致盲眼病.近年来包括血管内皮生长因子、碱性成纤维细胞生长因子、肿瘤坏死因子-α、转化生长因子、基质金属蛋白酶、胰岛素样生长因子1、血管生成素、血小板衍生生长因子、肝细胞生长因子等的细胞因子在渗出型AMD病程中的作用得到了较为深入的研究.这些细胞因子在促进新生血管形成、慢性炎症及纤维化进程中发挥重要作用,对其作用机制的研究可能为AMD新的治疗靶点提供线索.
年齡相關性黃斑變性(age-related macular degeneration,AMD),是髮達國傢50歲以上人群常見的緻盲眼病.近年來包括血管內皮生長因子、堿性成纖維細胞生長因子、腫瘤壞死因子-α、轉化生長因子、基質金屬蛋白酶、胰島素樣生長因子1、血管生成素、血小闆衍生生長因子、肝細胞生長因子等的細胞因子在滲齣型AMD病程中的作用得到瞭較為深入的研究.這些細胞因子在促進新生血管形成、慢性炎癥及纖維化進程中髮揮重要作用,對其作用機製的研究可能為AMD新的治療靶點提供線索.
년령상관성황반변성(age-related macular degeneration,AMD),시발체국가50세이상인군상견적치맹안병.근년래포괄혈관내피생장인자、감성성섬유세포생장인자、종류배사인자-α、전화생장인자、기질금속단백매、이도소양생장인자1、혈관생성소、혈소판연생생장인자、간세포생장인자등적세포인자재삼출형AMD병정중적작용득도료교위심입적연구.저사세포인자재촉진신생혈관형성、만성염증급섬유화진정중발휘중요작용,대기작용궤제적연구가능위AMD신적치료파점제공선색.
Age-related macular degeneration (AMD) is one of the most common causes of blindness in 50 year-old or more patients in the developed country.While the pathogenesis is complicated, many cytokines are involved in wet AMD pathogenesis, such as vascular endothelial growth factor, basic fibroblast growth factor, tumor necrosis factor-α, transforming growth factor, matrix metalloproteinases, insulin-like growth factor 1, angiopoietin, platelet derived growth factor and hepatocyte growth factor, which play important roles in promoting angiogenesis, inflammation and fibrosis.Action mechanisms investigations on those associated cytokines may represent potential therapeutic targets for AMD.
