中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
Chinese Journal of Laboratory Medicine
2015年
10期
657-660
,共4页
前列腺肿瘤%早期诊断%肿瘤标记,生物学%预后
前列腺腫瘤%早期診斷%腫瘤標記,生物學%預後
전렬선종류%조기진단%종류표기,생물학%예후
Prostatic neoplasms%Early diagnosis%Tumor markers,biological%Prognosis
受环境及生活方式转变等多因素的影响，前列腺癌成为老年男性常见的恶性肿瘤。血清前列腺特异性抗原的广泛应用，显著改变了前列腺癌的诊断和治疗。然而，作为前列腺癌筛选指标的前列腺特异抗原检测导致的前列腺癌患者过度诊治引起了学术界较大争议，另其在前列腺癌预测、治疗以及辅助临床决策的准确性也存在缺陷。因此，临床迫切需要新标志物来补充前列腺癌的监测和管理。本文对前列腺癌早期诊断及预后监测方面的新标志物进行了概括阐述，以期为前列腺癌的临床诊断及预后评估提供参考依据。（中华检验医学杂志，2015，38：657－660）
受環境及生活方式轉變等多因素的影響，前列腺癌成為老年男性常見的噁性腫瘤。血清前列腺特異性抗原的廣汎應用，顯著改變瞭前列腺癌的診斷和治療。然而，作為前列腺癌篩選指標的前列腺特異抗原檢測導緻的前列腺癌患者過度診治引起瞭學術界較大爭議，另其在前列腺癌預測、治療以及輔助臨床決策的準確性也存在缺陷。因此，臨床迫切需要新標誌物來補充前列腺癌的鑑測和管理。本文對前列腺癌早期診斷及預後鑑測方麵的新標誌物進行瞭概括闡述，以期為前列腺癌的臨床診斷及預後評估提供參攷依據。（中華檢驗醫學雜誌，2015，38：657－660）
수배경급생활방식전변등다인소적영향，전렬선암성위노년남성상견적악성종류。혈청전렬선특이성항원적엄범응용，현저개변료전렬선암적진단화치료。연이，작위전렬선암사선지표적전렬선특이항원검측도치적전렬선암환자과도진치인기료학술계교대쟁의，령기재전렬선암예측、치료이급보조림상결책적준학성야존재결함。인차，림상박절수요신표지물래보충전렬선암적감측화관리。본문대전렬선암조기진단급예후감측방면적신표지물진행료개괄천술，이기위전렬선암적림상진단급예후평고제공삼고의거。（중화검험의학잡지，2015，38：657－660）
Affected by many factors such as environment and lifestyle change , prostate cancer has become common malignancy in older men . The introduction and widespread adoption of PSA has revolutionized the way prostate cancer is diagnosed and treated .However , the use of PSA has also led to over-diagnosis and overtreatment of prostate cancer resulting in controversy about its use for screening .PSA also has limited predictive accuracy for predicting outcomes after treatment and for making clinical decisions about adjuvant and salvage therapies .Hence, there is an urgent need for novel biomarkers to supplement PSA for detection and management of prostate cancer .In this review, we discuss the traditional and new relevant molecular markers of early diagnosis and prognosis of prostate cancer for clinical diagnosis and prognosis of prostate cancer providing a reference .
