CAJ | 학술논문

目的：探讨中国汉族人群一氧化氮合酶1接头蛋白（ NOS1AP）基因rs348624多态性与早发性精神分裂症的易感性及其首发年龄的关联性。方法：选取285例早发性精神分裂症患者为研究组和826名正常对照组，采用TaqMan法，检测NOS1AP基因rs348624位点多态性，并分析研究组危险等位基因的频率与首发年龄的关联性。结果：研究组与对照组rs348624等位基因和基因型频率分布比较差异有统计学意义[χ2=149.17，自由度（df）=1，p=0.00；χ2=137.25，自由度（df）=2，p=0.00]；Kap-lan-Meier分析显示，rs348624等位基因T的频率与早发性精神分裂症首发年龄显著相关（ Kaplan-Meier log rank 检验p=0.00）。结论：在中国汉族人群中NOS1AP基因与早发性精神分裂症存在关联，其rs348624多态性可能是导致早发性精神分裂症患者发病年龄提前的重要因素。
목적：탐토중국한족인군일양화담합매1접두단백（ NOS1AP）기인rs348624다태성여조발성정신분렬증적역감성급기수발년령적관련성。방법：선취285례조발성정신분렬증환자위연구조화826명정상대조조，채용TaqMan법，검측NOS1AP기인rs348624위점다태성，병분석연구조위험등위기인적빈솔여수발년령적관련성。결과：연구조여대조조rs348624등위기인화기인형빈솔분포비교차이유통계학의의[χ2=149.17，자유도（df）=1，p=0.00；χ2=137.25，자유도（df）=2，p=0.00]；Kap-lan-Meier분석현시，rs348624등위기인T적빈솔여조발성정신분렬증수발년령현저상관（ Kaplan-Meier log rank 검험p=0.00）。결론：재중국한족인군중NOS1AP기인여조발성정신분렬증존재관련，기rs348624다태성가능시도치조발성정신분렬증환자발병년령제전적중요인소。
Objective:To investigate the association between the Nitric oxide synthase 1 adaptor protein (NOS1AP)gene polymorphisms with early-onset schizophrenia in the Han Chinese population. Method:NOS1AP tag single nucleotide polymorphisms(tag SNPs)rs348624 were genotyped using TaqMan SNP genoty-ping assay in 285 early-onset schizophrenia patients and 826 healthy controls. The allele and genotype frequen-cies were performed and the association with age at onset was evaluated. Results:There were significant difference in allele and genotype frequencies between patients and control subjects for rs348624(χ2 =149. 17, df=1,p=0. 00;χ2 =137. 25,df=2,p=0. 00). The T allele was significantly associated with an earlier age of onset in early-onset schizophrenia patients(Kaplan-Meier log rank test p=0. 00). Conclusion:The NOS1AP gene rs348624 polymorphisms may play important roles in the susceptibility and onset age to early-onset schizo-phrenia in the Han Chinese population.