CAJ | 학술논문

食管良性狭窄是临床常见疾病之一，其首选治疗方案为内镜下扩张。对于扩张效果不佳的顽固性食管狭窄其治疗干预措施有限。丝裂霉素C （ Mitomycin-C， MMC）是一种兼具抗肿瘤和抑制增殖双重作用的抗生素，作为抗增殖抗生素最先运用于眼科领域，局部辅助应用MMC可成为顽固性食管狭窄可行安全的改善疗法。文中旨在对近年腐蚀性食管狭窄、内镜黏膜下剥离术后食管狭窄、食管闭锁修复术后食管狭窄、放疗后食管狭窄以及局部应用MMC改善狭窄现状作一综述。
식관량성협착시림상상견질병지일，기수선치료방안위내경하확장。대우확장효과불가적완고성식관협착기치료간예조시유한。사렬매소C （ Mitomycin-C， MMC）시일충겸구항종류화억제증식쌍중작용적항생소，작위항증식항생소최선운용우안과영역，국부보조응용MMC가성위완고성식관협착가행안전적개선요법。문중지재대근년부식성식관협착、내경점막하박리술후식관협착、식관폐쇄수복술후식관협착、방료후식관협착이급국부응용MMC개선협착현상작일종술。
Gastrointestinal benign stricture is one of common diseases in clinics , endoscopic dilation is its preferred treatment . However , for the dilation ineffective refractory strictures , it represents a difficult management problem given the limited therapeutic in-terventions available .Mitomycin-C is an antibiotic which has the dual role of anti-tumor and anti-proliferation.As an anti-proliferative drug, it was first applied in the field of ophthalmology .Local auxiliary application of MMC can be a feasible and safe measurement to improve the efficacy of refractory esophageal strictures .The aim of this study is to perform a systematic review which employs mitomycin C in the treatment of refractory esophageal strictures caused by corrosion , endoscopic submucosal dissection , esophageal atresia repara-tion and radiotherapy .