CAJ | 학술논문

糖尿病肾病（ Diabetic Nephropathy ， DN）发病受多方面因素的影响。越来越多证据表明，肾组织中炎症细胞浸润和促炎因子过表达所引起的机体免疫调节异常在DN的发生发展中起着关键作用。活性维生素D3作为一种新型免疫调节剂，不仅可以抑制炎性因子，还能够调节免疫反应。作者从免疫细胞、细胞因子及肾素-血管紧张素系统（ renin-angiotensinsys-tem， RAS）3方面分别综述了与DN有关的活性维生素D3作用机制，着重讨论了巨噬细胞、T淋巴细胞、树突状细胞、转化生长因子-β（ transforming growth factor-β，TGF-β）、RAS等的肾损伤机制与活性维生素D3的免疫调节作用。
당뇨병신병（ Diabetic Nephropathy ， DN）발병수다방면인소적영향。월래월다증거표명，신조직중염증세포침윤화촉염인자과표체소인기적궤체면역조절이상재DN적발생발전중기착관건작용。활성유생소D3작위일충신형면역조절제，불부가이억제염성인자，환능구조절면역반응。작자종면역세포、세포인자급신소-혈관긴장소계통（ renin-angiotensinsys-tem， RAS）3방면분별종술료여DN유관적활성유생소D3작용궤제，착중토론료거서세포、T림파세포、수돌상세포、전화생장인자-β（ transforming growth factor-β，TGF-β）、RAS등적신손상궤제여활성유생소D3적면역조절작용。
Diabetic nephropathy is caused by manifold factors .Increasing evidences suggest that immunoregulation abnormality caused by inflammatory cell infiltration and proinflammatory factor overexpression in kidney tissue has a key role in the occurrence and development of diabetic nephropathy .As a novel immunomodulator , activated vitamin D 3 could inhibit inflammatory factor and regulate immunity response .The author reviews the effect of activated vitamin D 3 related to diabetic nephropathy , from the pointviews of immu-nocyte, cytokines and rennin-angiotensin system.The roles of macrophage, T lymphocytes, dendritic cell, transforming growth factor-β1, and rennin-angiotensin system in kidney injury and immunal regulation of activated vitamin D 3 are discussed.