CAJ | 학술논문

椎间盘退行性变是骨科常见的疾病之一，其复杂生理病理改变受到多种因素调控。其中基质金属蛋白酶（ ma-trix metallo proteinases ， MMPs）及其调节因子起到极为重要的作用，并且MMPs影响椎间盘退变的因素之间又相互联系、相互作用。因此近年来针对MMPs的研究已逐渐成为明确椎间盘退变诱因的热点之一。文中分析了导致椎间盘发生退变的因素，并根据MMPs各家族成员的不同功能，分别归纳了不同种类MMPs的表达与椎间盘退变的关系，阐述了MMP可通过基因多态性及相关因子的调节，对椎间盘退变的产生影响。
추간반퇴행성변시골과상견적질병지일，기복잡생리병리개변수도다충인소조공。기중기질금속단백매（ ma-trix metallo proteinases ， MMPs）급기조절인자기도겁위중요적작용，병차MMPs영향추간반퇴변적인소지간우상호련계、상호작용。인차근년래침대MMPs적연구이축점성위명학추간반퇴변유인적열점지일。문중분석료도치추간반발생퇴변적인소，병근거MMPs각가족성원적불동공능，분별귀납료불동충류MMPs적표체여추간반퇴변적관계，천술료MMP가통과기인다태성급상관인자적조절，대추간반퇴변적산생영향。
Intervertebral disc degeneration is one of the orthopedic common diseases , its complex physiopathological changes are regulated by many factors .The matrix metalloproteinases ( MMPs) and its regulatoryl factors play a very important role , and the factors that affect the role of MMPs in intervertebral disc degeneration interact with each other .So MMPs have gradually become one of the hot spot of intervertebral disc degeneration in recent years .In this paper , we first analyze the factors that cause the degeneration of intervertebral disc .Then we summarize the relationship between the expression of MMPs and the degeneration of intervertebral disc ac -cording to the different function of MMPs members in the family .Finally we state that MMPs can have an effect on the degeneration of intervertebral disc by the regulation of gene polymorphism and the related factors .