CAJ | 학술논문

炎性小体是一种多蛋白复合体，它能够识别多种病原微生物及应激相关内源性信号分子，在固有免疫中发挥重要作用。炎性小体可通过活化半胱氨酸天冬氨酸酶-1（caspase-1）诱导促炎因子IL-1β和IL-18的成熟、释放，引起炎性反应，参与多种疾病如家族性周期性自身炎性反应、缺血再灌注损伤和动脉粥样硬化等的发生发展过程。
염성소체시일충다단백복합체，타능구식별다충병원미생물급응격상관내원성신호분자，재고유면역중발휘중요작용。염성소체가통과활화반광안산천동안산매-1（caspase-1）유도촉염인자IL-1β화IL-18적성숙、석방，인기염성반응，삼여다충질병여가족성주기성자신염성반응、결혈재관주손상화동맥죽양경화등적발생발전과정。
Inflammasomes are multiprotein complexes that can recognize pathogenic microorganisms and stress -asso-ciated endogenous molecules and play an important role in innate immune system .Inflammasomes cause inflamma-tion response by inducing maturation of inflammatory cytokines interleukin ( IL)-1βand IL-18 through activation of caspase-1 ,and involve in the pathogenesis of various diseases such as cryopyrin-associated periodic syndrome , is-chemia-reperfusion injury and atherosclerosis .