基础医学与临床
基礎醫學與臨床
기출의학여림상
Basic & Clinical Medicine
2015年
1期
104-107
,共4页
膜联蛋白A5%疾病%机制
膜聯蛋白A5%疾病%機製
막련단백A5%질병%궤제
annexin A5%disease%mechanism
Annexin A5(膜联蛋白A5)是Ca2+依赖的磷脂结合蛋白家族的一名成员,它存在于组织细胞中,因为其具有的独特结构而参加多种细胞内、外的抗凝,促凋亡等重要功能。并且Annexin A5与系统性红斑狼疮、肿瘤等多种疾病的发病机制有着一定关联性。
Annexin A5(膜聯蛋白A5)是Ca2+依賴的燐脂結閤蛋白傢族的一名成員,它存在于組織細胞中,因為其具有的獨特結構而參加多種細胞內、外的抗凝,促凋亡等重要功能。併且Annexin A5與繫統性紅斑狼瘡、腫瘤等多種疾病的髮病機製有著一定關聯性。
Annexin A5(막련단백A5)시Ca2+의뢰적린지결합단백가족적일명성원,타존재우조직세포중,인위기구유적독특결구이삼가다충세포내、외적항응,촉조망등중요공능。병차Annexin A5여계통성홍반랑창、종류등다충질병적발병궤제유착일정관련성。
Annexin A5 is a member of Ca 2+-dependent phospholipid binding proteins family .It exists in histocytes . And because of its unique structure , Annexin A5 plays an important role in many critical functions such as cell in-side/outside anticoagulation and pro-apoptosis .Moreover , Annexin A5 has certain relevance with many diseases such as systemic lupus erythematosus ,tumour and other diseases .