CAJ | 학술논문

目的：探讨尿蛋白电泳在狼疮性肾炎和原发性肾病综合征鉴别诊断中的作用。方法对39例狼疮性肾炎和44例原发性肾病综合征患者的流行病学数据、尿蛋白电泳及相关常规实验室检查结果进行卡方检验；分析狼疮性肾炎与原发性肾病综合征患者肾活检病理结果，计算肾小管间质病变评分，进行方差分析。结果患者流行病学数据与既往研究相符，狼疮性肾炎患者混合性蛋白尿发生率及肾小管间质病变评分明显高于原发性肾病综合征患者，但两组患者在高血压发病率及血肌酐升高方面无明显差异。结论蛋白尿电泳有助于鉴别狼疮性肾炎与原发性肾病综合征，并且对肾脏病变的预后有一定指示意义。
목적：탐토뇨단백전영재랑창성신염화원발성신병종합정감별진단중적작용。방법대39례랑창성신염화44례원발성신병종합정환자적류행병학수거、뇨단백전영급상관상규실험실검사결과진행잡방검험；분석랑창성신염여원발성신병종합정환자신활검병리결과，계산신소관간질병변평분，진행방차분석。결과환자류행병학수거여기왕연구상부，랑창성신염환자혼합성단백뇨발생솔급신소관간질병변평분명현고우원발성신병종합정환자，단량조환자재고혈압발병솔급혈기항승고방면무명현차이。결론단백뇨전영유조우감별랑창성신염여원발성신병종합정，병차대신장병변적예후유일정지시의의。
Objective To explore the role of urine protein electrophoresis in the differentiation diagnosis of lupus nephritis and primary nephrotic syndrome.Methods The epidemiologic data of 39 patients with lupus nephritis and 44 patients with pri‐mary nephrotic syndrome were collected and statistically analyzed.The urine protein electrophoresis and relevant routine lab tests were performed ,and the c2 test was conducted.Besides ,the renal biopsy results of patients with lupus nephritis or primary nephrotic syndrome were analyzed ,the tubular‐interstitial lesion (TIL ) was scored and the variance analysis was pre‐formed.Results The epidemiologic data was consistent with former studies ,which revealed that patients with lupus nephritis were more likely to have mixed proteinuria and higher TIL score ,but there was no difference in the occurrence of hypertension or serum creatinine increase between the two groups.Conclusion Urine protein electrophoresis can be used for differentiation of lupus nephritis and primary nephrotic syndrome and it might predict the prognosis of renal disease.