实用疼痛学杂志
實用疼痛學雜誌
실용동통학잡지
Pain Clinic Journal
2015年
3期
173-176
,共4页
帕瑞昔布%舒芬太尼%血管内皮生长因子C%肿瘤坏死因子α%白介素1β%乳腺肿瘤
帕瑞昔佈%舒芬太尼%血管內皮生長因子C%腫瘤壞死因子α%白介素1β%乳腺腫瘤
파서석포%서분태니%혈관내피생장인자C%종류배사인자α%백개소1β%유선종류
Parecoxib%Sufentanil%VEGF-C%TNF-α%IL-1β%Breast neoplasms
目的 探讨帕瑞昔布术后镇痛对乳腺癌患者术后血浆VEGF-C、TNF-α、IL-1β的影响.方法 拟行乳腺癌改良根治术患者40例,随机分为舒芬太尼组(SF组)和帕瑞昔布组(P组).分别在麻醉诱导前、手术结束时、术后48 h时测定血浆中VEGF-C、TNF-α、IL-1β浓度.记录两组患者术后2、24、48 h VAS、术后48 h内不良反应(恶心、呕吐)的发生例数及舒芬太尼消耗总量.结果 与SF组比较,P组患者术后48 h血浆VEGF-C、TNF-α、IL-1β浓度均显著降低(P＜0.05).两组患者不同时点VAS评分差异无统计学意义(P＞0.05),但SF组患者不良反应的发生率明显高于P组(P＜0.05).术后48 h内舒芬太尼消耗总量SF组多于P组(P＜0.05).结论 帕瑞昔布术后镇痛能明显降低乳腺癌患者术后血浆VEGF-C、TNF-α、IL-1β的浓度.
目的 探討帕瑞昔佈術後鎮痛對乳腺癌患者術後血漿VEGF-C、TNF-α、IL-1β的影響.方法 擬行乳腺癌改良根治術患者40例,隨機分為舒芬太尼組(SF組)和帕瑞昔佈組(P組).分彆在痳醉誘導前、手術結束時、術後48 h時測定血漿中VEGF-C、TNF-α、IL-1β濃度.記錄兩組患者術後2、24、48 h VAS、術後48 h內不良反應(噁心、嘔吐)的髮生例數及舒芬太尼消耗總量.結果 與SF組比較,P組患者術後48 h血漿VEGF-C、TNF-α、IL-1β濃度均顯著降低(P＜0.05).兩組患者不同時點VAS評分差異無統計學意義(P＞0.05),但SF組患者不良反應的髮生率明顯高于P組(P＜0.05).術後48 h內舒芬太尼消耗總量SF組多于P組(P＜0.05).結論 帕瑞昔佈術後鎮痛能明顯降低乳腺癌患者術後血漿VEGF-C、TNF-α、IL-1β的濃度.
목적 탐토파서석포술후진통대유선암환자술후혈장VEGF-C、TNF-α、IL-1β적영향.방법 의행유선암개량근치술환자40례,수궤분위서분태니조(SF조)화파서석포조(P조).분별재마취유도전、수술결속시、술후48 h시측정혈장중VEGF-C、TNF-α、IL-1β농도.기록량조환자술후2、24、48 h VAS、술후48 h내불량반응(악심、구토)적발생례수급서분태니소모총량.결과 여SF조비교,P조환자술후48 h혈장VEGF-C、TNF-α、IL-1β농도균현저강저(P＜0.05).량조환자불동시점VAS평분차이무통계학의의(P＞0.05),단SF조환자불량반응적발생솔명현고우P조(P＜0.05).술후48 h내서분태니소모총량SF조다우P조(P＜0.05).결론 파서석포술후진통능명현강저유선암환자술후혈장VEGF-C、TNF-α、IL-1β적농도.
Objective To evaluate the effects ofparecoxib on serum VEGF-C,TNF-αand IL-1β concentrations in female patients undergoing surgery for breast cancer during postoperative analgesia.Methods Forty female patients with primary breast cancer undergoing modified radical mastectomy were randomly divided into receiving postoperative analgesia with parecoxib (P group) and sufentanil (SF group) respectively.Venous blood was sampled before anesthesia, at the end of surgery and at 48 h after the surgery.The samples were analyzed to determine the serum VEGF-C, TNF-α, IL-1 β concentrations.VAS was recorded at postoperative 2,24,48 h respectively.Side effects (including nausea and vomiting) and the amount of sufentanil used during 48 h were also recorded.Results Compared with group SF, the serum levels VEGF-C, TNF-α, IL-1β in group P decreased markedly (P ＜ 0.05).No difference was found in V AS between the two groups (P＞ 0.05) in all observed time.The incidence of side-effects and the consumption of sufentanil during postoperative 48 h in group P were less than those in group SF (P＜ 0.05).Conclusion Postoperative analgesia with parecoxib decreases the serum concentrations of VEGF-C, TNF-α, IL-1 β in female patients undergoing surgery for breast cancer.
