CAJ | 학술논문

磷脂酰肌醇3激酶在肿瘤细胞信号转导中起着重要的调节作用,许多因子可以使磷脂酰肌醇3-激酶活化,引起蛋白激酶B与细胞膜的结合,在磷酸肌醇依赖激酶的参与下,蛋白激酶B和苏氨酸和丝氨酸残基发生磷酸化而活化,进入胞质和胞核,激活细胞内酶促级联反应,从而产生生物学效应,其与肿瘤细胞恶性增殖、血管新生和糖酵解有密切的关系.
린지선기순3격매재종류세포신호전도중기착중요적조절작용,허다인자가이사린지선기순3-격매활화,인기단백격매B여세포막적결합,재린산기순의뢰격매적삼여하,단백격매B화소안산화사안산잔기발생린산화이활화,진입포질화포핵,격활세포내매촉급련반응,종이산생생물학효응,기여종류세포악성증식、혈관신생화당효해유밀절적관계.
Phosphatidylinositol 3-kinase (PI3K) plays an important role in the regulation and signal transduction of tumor cells.PI3K is activated by many factors, which leads to protein kinase B (PKB or Akt) binding to cell membrane.With the help of the phosphoinositide-dependent kinase in the PI3K/Akt signal transduction pathway, Akt is phosphorylated with threonine and serine, activated and enters the cytoplasm and nucleus, which mediates enzymatic cascade reaction to produce biological effects.It is closely related with proliferation,angiogenesis and glycolysis of malignant tumor cells.