国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
International Journal of Respiration
2015年
19期
1510-1512
,共3页
全外显子组%全外显子组测序%肺癌
全外顯子組%全外顯子組測序%肺癌
전외현자조%전외현자조측서%폐암
Whole-exome%Whole-exome sequencing%Lung cancer
全外显子组是人类全部外显子组区域的总称,全外显子组测序又称为定向外显子组捕获,可选择性地对人类基因组的编码区进行测序,以发现常见疾病相关的异常基因.因为全外显子组测序相比人类全基因组测序成本低、效率高,目前在疾病诊断中应用越来越多.本文主要对当前临床上全外显子组测序技术及其在肺癌研究中的应用等问题进行综述.
全外顯子組是人類全部外顯子組區域的總稱,全外顯子組測序又稱為定嚮外顯子組捕穫,可選擇性地對人類基因組的編碼區進行測序,以髮現常見疾病相關的異常基因.因為全外顯子組測序相比人類全基因組測序成本低、效率高,目前在疾病診斷中應用越來越多.本文主要對噹前臨床上全外顯子組測序技術及其在肺癌研究中的應用等問題進行綜述.
전외현자조시인류전부외현자조구역적총칭,전외현자조측서우칭위정향외현자조포획,가선택성지대인류기인조적편마구진행측서,이발현상견질병상관적이상기인.인위전외현자조측서상비인류전기인조측서성본저、효솔고,목전재질병진단중응용월래월다.본문주요대당전림상상전외현자조측서기술급기재폐암연구중적응용등문제진행종술.
Whole-exome refers to the human whole exome region.Whole-exome sequencing (WES), also known as targeted exome capture, can selectively sequence human coding region in the genome in order to find mutative genes associated with common diseases.WES is more cost-effective and efficient than the whole genome sequencing, therefore, WES is used more frequently in the diagnosis of diseases.This review introduces the technology of WES and its applications in lung cancer.
