中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2015年
40期
3293-3296
,共4页
宗允%段鹏%丁浔%司涟%刘佳%涂萍
宗允%段鵬%丁潯%司漣%劉佳%塗萍
종윤%단붕%정심%사련%류가%도평
糖尿病前期%生活方式%早期干预%营养管理
糖尿病前期%生活方式%早期榦預%營養管理
당뇨병전기%생활방식%조기간예%영양관리
Prediabetic state%Life style%Early intervention%Nutritional management
目的 探讨生活方式及量化营养干预对糖尿病前期人群的影响.方法 收集2011年1月至2012年1月在南昌市系马桩及广润门两个社区流行病学调查中确诊为糖尿病前期的患者214例,随机分为干预组及对照组各107例,干预组进行生活方式及量化营养干预,对照组给予常规的生活方式干预,测量身高、体质量计算体质指数,采用葡萄糖氧化酶法检测血糖,高效液相色谱法检测糖化血红蛋白.随访2年,对比两组干预前后各项指标变化及糖尿病转归情况.本研究通过南昌市第三医院医学研究伦理委员会批准.结果 对照组和干预组干预前各项指标比较差异均无统计学意义(均P>0.05).干预组87例(81.3%)、对照组84例(78.5%)完成2年随访.随访2年后,对照组与基线各指标比较差异均无统计学意义(均P>0.05).干预组体质量、体质指数、空腹血糖、餐后2 h血糖、糖化血红蛋白等指标均有明显下降,差异均有统计学意义(均P<0.05).对照组11 例(13.1%)进展为糖尿病,1 例(1.2%)为正常糖耐量.干预组3 例(3.4%)进展为糖尿病,7 例(8.0%)为正常糖耐量,两组比较差异有统计学意义(P<0.05).以发生糖尿病为终点,进行cox比例风险回归模型分析,对照组发生糖尿病的风险明显高于干预组[ HR =3.903,95%CI:1.089 ~13.992,P=0.037].结论 生活方式及量化营养干预可改善糖尿病前期人群血糖控制,延缓其向糖尿病的进展.
目的 探討生活方式及量化營養榦預對糖尿病前期人群的影響.方法 收集2011年1月至2012年1月在南昌市繫馬樁及廣潤門兩箇社區流行病學調查中確診為糖尿病前期的患者214例,隨機分為榦預組及對照組各107例,榦預組進行生活方式及量化營養榦預,對照組給予常規的生活方式榦預,測量身高、體質量計算體質指數,採用葡萄糖氧化酶法檢測血糖,高效液相色譜法檢測糖化血紅蛋白.隨訪2年,對比兩組榦預前後各項指標變化及糖尿病轉歸情況.本研究通過南昌市第三醫院醫學研究倫理委員會批準.結果 對照組和榦預組榦預前各項指標比較差異均無統計學意義(均P>0.05).榦預組87例(81.3%)、對照組84例(78.5%)完成2年隨訪.隨訪2年後,對照組與基線各指標比較差異均無統計學意義(均P>0.05).榦預組體質量、體質指數、空腹血糖、餐後2 h血糖、糖化血紅蛋白等指標均有明顯下降,差異均有統計學意義(均P<0.05).對照組11 例(13.1%)進展為糖尿病,1 例(1.2%)為正常糖耐量.榦預組3 例(3.4%)進展為糖尿病,7 例(8.0%)為正常糖耐量,兩組比較差異有統計學意義(P<0.05).以髮生糖尿病為終點,進行cox比例風險迴歸模型分析,對照組髮生糖尿病的風險明顯高于榦預組[ HR =3.903,95%CI:1.089 ~13.992,P=0.037].結論 生活方式及量化營養榦預可改善糖尿病前期人群血糖控製,延緩其嚮糖尿病的進展.
목적 탐토생활방식급양화영양간예대당뇨병전기인군적영향.방법 수집2011년1월지2012년1월재남창시계마장급엄윤문량개사구류행병학조사중학진위당뇨병전기적환자214례,수궤분위간예조급대조조각107례,간예조진행생활방식급양화영양간예,대조조급여상규적생활방식간예,측량신고、체질량계산체질지수,채용포도당양화매법검측혈당,고효액상색보법검측당화혈홍단백.수방2년,대비량조간예전후각항지표변화급당뇨병전귀정황.본연구통과남창시제삼의원의학연구윤리위원회비준.결과 대조조화간예조간예전각항지표비교차이균무통계학의의(균P>0.05).간예조87례(81.3%)、대조조84례(78.5%)완성2년수방.수방2년후,대조조여기선각지표비교차이균무통계학의의(균P>0.05).간예조체질량、체질지수、공복혈당、찬후2 h혈당、당화혈홍단백등지표균유명현하강,차이균유통계학의의(균P<0.05).대조조11 례(13.1%)진전위당뇨병,1 례(1.2%)위정상당내량.간예조3 례(3.4%)진전위당뇨병,7 례(8.0%)위정상당내량,량조비교차이유통계학의의(P<0.05).이발생당뇨병위종점,진행cox비례풍험회귀모형분석,대조조발생당뇨병적풍험명현고우간예조[ HR =3.903,95%CI:1.089 ~13.992,P=0.037].결론 생활방식급양화영양간예가개선당뇨병전기인군혈당공제,연완기향당뇨병적진전.
Objective To explore the impact of lifestyle and quantitative nutrition intervention on individuals with prediabetes.Methods A total of 214 prediabetic patients from epidemiologic survey in Ximazhuang and Guangrunmen community centers in Nanchang from January 2011 to January 2012 were enrolled in the study.All the participants were randomly divided into two groups:the intervention group and the control group, with 107 patients in each group.Intensified lifestyle and quantitative nutrition interventions were carried out in the intervention group , and routine lifestyle intervention was carried out in control group.Height and weight were measured , and the body mass index (BMI) was calculated.Blood glucose was tested by glucose oxidase method , and glycosylated hemoglobin (HbA1c) was detected by high performance liquid chromatography.Various parameter changes were compared between two groups after two year's follow-up, and the outcome data of patients was collected.The study was approved by the Ethics Committee of the Third Hospital of Nanchang.Results There were no significant differences in each parameter between two groups before intervention (all P>0.05).No obvious change was found for the parameters in the control group after two year's follow-up (all P>0.05), but weight, BMI, fasting blood glucose, postprandial two-hour blood glucose and HbA1c decreased in the intervention group (P<0.05).There were 11 (13.1%) diabetic cases and 1 (1.2%) participant with normal glucose tolerance in the control group, and 3 (3.4%) diabetic cases and 7 (8.0%) participants with normal glucose tolerance in the intervention group (P<0.05).The risk of diabetes in two groups was performed using cox regression model analysis , and the primary end-point was the incidence of diabetes.The risk of diabetes in the control group was significantly higher than that in the intervention group [ HR=3.903, 95%CI:1.089-13.992, P=0.037 ].Conclusion The lifestyle and quantitative nutrition interventions may improve the blood glucose control and delay the progression of diabetes in prediabetes patients.