CAJ | 학술논문

目的分析IgG4相关性疾病的临床特征.方法回顾分析2011年12月至2015年1月北京医院确诊的14例IgG4相关性疾病患者的临床表现、影像和病理学资料.结果 14例患者中男、女各7例,年龄(64.3 ±10.0)岁.10例存在≥2个器官受累,受累器官包括胰腺10例次,胆管和涎腺各5例次,肺4例次,泪腺2例次.14例患者中5例血清IgG水平升高,14例血清IgG4水平均升高,7例血嗜酸粒细胞绝对值升高,12例检查IgE的患者中9例升高.14例患者预后均良好,其中有13例应用糖皮质激素治疗,治疗后临床症状、影像学表现明显好转,IgG4水平降低,但仅有2例降至正常.结论 IgG4相关性疾病临床表现多样,多器官受累常见.血IgG、IgE及嗜酸粒细胞升高可作为该疾病的诊断线索.
목적 분석IgG4상관성질병적림상특정.방법 회고분석2011년12월지2015년1월북경의원학진적14례IgG4상관성질병환자적림상표현、영상화병이학자료.결과 14례환자중남、녀각7례,년령(64.3 ±10.0)세.10례존재≥2개기관수루,수루기관포괄이선10례차,담관화연선각5례차,폐4례차,루선2례차.14례환자중5례혈청IgG수평승고,14례혈청IgG4수평균승고,7례혈기산립세포절대치승고,12례검사IgE적환자중9례승고.14례환자예후균량호,기중유13례응용당피질격소치료,치료후림상증상、영상학표현명현호전,IgG4수평강저,단부유2례강지정상.결론 IgG4상관성질병림상표현다양,다기관수루상견.혈IgG、IgE급기산립세포승고가작위해질병적진단선색.
Objective To summarize the clinical characteristics of IgG 4 related disease.Methods A retrospective analysis of clinical manifestation , radiography and pathological information of patients diagnosed with IgG4 related disease in Beijing Hospital.Results Patients recruited in this study were 7 males and 7 females at the average age of (64.3 ±10.0) years old.Equal or greater than two organs were suffered in 10 patients.In these involved organs , pancreas was the most suffered organ with 10 times, bile duct and salivary gland was suffered 5 times respectively , lung was suffered 4 times and lacrimal gland was suffered 2 times.Laboratory examination of these 14 cases showed that 5 of these cases were with increased level of plasma IgG and all of the cases were with increased level of IgG 4, 7 patients were with increased level of eosinophil count and 9 patients in 12 cases were with the increased level of IgE.All of the diagnosed patients were eusemia and 13 of them received the treatment of glucocorticoid.After usage of glucocorticoid , the clinical symptom and radiography findings were at great improvement , and the levels of IgG4 were decreased , but only two cases were down to normal level.Conclusions IgG4 related disease is a kind of disease with various manifestation and multiple organs are commonly suffered.The increase of IgG , IgE levels and eosinophil count could be considered as diagnosis clues.