中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
Chinese Journal of Diabetes Mellitus
2015年
10期
619-623
,共5页
沈艳军%田亚强%毕会民%李明%孙洁%段洪刚%申爱方
瀋豔軍%田亞彊%畢會民%李明%孫潔%段洪剛%申愛方
침염군%전아강%필회민%리명%손길%단홍강%신애방
糖尿病,妊娠%实时动态血糖监测%围手术期
糖尿病,妊娠%實時動態血糖鑑測%圍手術期
당뇨병,임신%실시동태혈당감측%위수술기
Diabetes mellitus,gestational%Real-time continuous glucose monitoring system%Perioperative period
目的 评价实时胰岛素泵系统在妊娠糖尿病(GDM)剖宫产围手术期的临床疗效. 方法 2012年4月至2013年12月选取具有剖宫产术指征的GDM患者,根据随机数字表法分为对照组(单C组)和试验组(3C组),单C组根据床边血糖监测结果调整胰岛素泵输注量,3C组根据动态血糖监测结果调整胰岛素泵输注量.比较两组患者围手术期血糖控制情况、胰岛素用量、低血糖发生率、切口愈合时间及新生儿不良结局.手术当天相关指标采用协方差分析,术后相关指标采用描述性分析.结果 (1)共56例患者入组,单C组30例,3C组26例,两组患者基线资料相似,术前血糖控制无明显差异;(2)手术当天3C治疗组根据RT-CGMS调整基础率次数较多,基础胰岛素用量明显少于单C组[(0.31±0.09 )比(0.38±0.11) U/kg],差异有统计学意义(t=2.62,P=0.03);基础率调整次数多于单C组(56比22次),低血糖次数及低血糖发生率均少于单C组(5比15次、15.4%比30%,χ2=4.60、2.61,均P<0.05);(3)分娩后两组患者胰岛素需要量明显减少,其中3C组14人,单C组11人停用胰岛素;(4)术后切口愈合时间及新生儿不良结局两组差异无统计学意义. 结论 实时胰岛素泵系统在GDM围手术期的血糖管理中具有安全、快速、有效地控制血糖的独特优势.
目的 評價實時胰島素泵繫統在妊娠糖尿病(GDM)剖宮產圍手術期的臨床療效. 方法 2012年4月至2013年12月選取具有剖宮產術指徵的GDM患者,根據隨機數字錶法分為對照組(單C組)和試驗組(3C組),單C組根據床邊血糖鑑測結果調整胰島素泵輸註量,3C組根據動態血糖鑑測結果調整胰島素泵輸註量.比較兩組患者圍手術期血糖控製情況、胰島素用量、低血糖髮生率、切口愈閤時間及新生兒不良結跼.手術噹天相關指標採用協方差分析,術後相關指標採用描述性分析.結果 (1)共56例患者入組,單C組30例,3C組26例,兩組患者基線資料相似,術前血糖控製無明顯差異;(2)手術噹天3C治療組根據RT-CGMS調整基礎率次數較多,基礎胰島素用量明顯少于單C組[(0.31±0.09 )比(0.38±0.11) U/kg],差異有統計學意義(t=2.62,P=0.03);基礎率調整次數多于單C組(56比22次),低血糖次數及低血糖髮生率均少于單C組(5比15次、15.4%比30%,χ2=4.60、2.61,均P<0.05);(3)分娩後兩組患者胰島素需要量明顯減少,其中3C組14人,單C組11人停用胰島素;(4)術後切口愈閤時間及新生兒不良結跼兩組差異無統計學意義. 結論 實時胰島素泵繫統在GDM圍手術期的血糖管理中具有安全、快速、有效地控製血糖的獨特優勢.
목적 평개실시이도소빙계통재임신당뇨병(GDM)부궁산위수술기적림상료효. 방법 2012년4월지2013년12월선취구유부궁산술지정적GDM환자,근거수궤수자표법분위대조조(단C조)화시험조(3C조),단C조근거상변혈당감측결과조정이도소빙수주량,3C조근거동태혈당감측결과조정이도소빙수주량.비교량조환자위수술기혈당공제정황、이도소용량、저혈당발생솔、절구유합시간급신생인불량결국.수술당천상관지표채용협방차분석,술후상관지표채용묘술성분석.결과 (1)공56례환자입조,단C조30례,3C조26례,량조환자기선자료상사,술전혈당공제무명현차이;(2)수술당천3C치료조근거RT-CGMS조정기출솔차수교다,기출이도소용량명현소우단C조[(0.31±0.09 )비(0.38±0.11) U/kg],차이유통계학의의(t=2.62,P=0.03);기출솔조정차수다우단C조(56비22차),저혈당차수급저혈당발생솔균소우단C조(5비15차、15.4%비30%,χ2=4.60、2.61,균P<0.05);(3)분면후량조환자이도소수요량명현감소,기중3C조14인,단C조11인정용이도소;(4)술후절구유합시간급신생인불량결국량조차이무통계학의의. 결론 실시이도소빙계통재GDM위수술기적혈당관리중구유안전、쾌속、유효지공제혈당적독특우세.
Objective To assess the efficacy of sensor-augmented insulin-pump (SAP) during the perioperative period of cesarean delivery in patients with gestational diabetes mellitus(GDM). Methods GDM patients with indications of cesarean section were randomized into experimental group and control group according to table of random number between April 2012 to December 2013. The experimental group was treated with continuous subcutaneous insulin infusion (CSII) titrated based on real-time continuous glucose monitoring system (RT-CGMS), while the control group was treated with CSII adjusted by point of care testing (POCT). The level of blood glucose, insulin dosage, incidence of hypoglycemia, incision healing time and neonatal adverse outcomes were compared between two groups. Covariance analysis was used for the related indicators at the day of surgery, and descriptive analysis was used for the analysis of the postoperative related indicators. Results (1) A total of 56 patients were enrolled, 30 in control group and 26 in experimental group. Baseline characteristics of the patients were comparable between two groups. (2) On the day of surgery, basal rate was adjusted more frequently in experimental group according to RT-CGMS. The dose of basal insulin in the experimental group was significantly lower than in the control group((0.31 ± 0.09)vs (0.38 ± 0.11) U/kg,t=2.62,P=0.03). The frequency of basal rate adjustment was more in the experimental group (56 vs 22, P<0.01). The frequency and incidence of hypoglycemia were lower in the experimental group than in the control group (5 vs 15, 15.4%vs 30%,χ2=4.60, 2.61, both P<0.05). (3) The 24 h insulin dose decreased significantly after childbirth in both groups. Insulin use was ceased in 14 patients of experimental group and 11 of control group. (4) No significant difference were observed in incision healing time and neonatal adverse outcomes between the two groups. Conclusion Sensor-augmented insulin-pump demonstrates unique advantage in controlling blood glucose of perioperative GDM patients.