国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
International Journal of Genetics
2015年
5期
237-241,286
,共6页
上调基因-4%癌基因%卵巢恶性上皮性肿瘤%免疫组化
上調基因-4%癌基因%卵巢噁性上皮性腫瘤%免疫組化
상조기인-4%암기인%란소악성상피성종류%면역조화
URG4%Oncogene%Epithelial ovarian carcinoma%Immunohistochemicatry
目的 探讨上调基因-4(URG4)在卵巢恶性上皮性肿瘤中的表达及其与各临床病理特征之间的关系.方法 采用免疫组化的方法检测50例卵巢恶性上皮性肿瘤组织、20例卵巢良性肿瘤组织、20例正常卵巢组织标本中URG4的表达情况,分析URG4的表达与各临床变量之间的关系.结果 卵巢恶性上皮性肿瘤组织中URG4主要表达于细胞浆中,呈现散在或弥散的棕黄色颗粒.URG4在卵巢恶性上皮性肿瘤组织中的阳性表达率(86%)高于卵巢良性肿瘤组织(40%)和正常卵巢组织(15%),差异具有统计学意义(x2=15.286,P<0.05;x2 =31.963,P<0.05).在不同年龄组及不同组织学类型的卵巢恶性上皮性肿瘤组织中,URG4的表达差异无统计学意义(x2 =0.166,P>0.05;x2=0.603,P>0.05);随着卵巢恶性上皮性肿瘤组织的临床期别、病理分级愈高,URG4的阳性表达也愈强,差异具有统计学意义(x2=8.449,P<0.05;x2=11.589,P<0.05),且有淋巴结转移者URG4的表达高于无淋巴结转移者,腹水中肿瘤细胞阳性者URG4的表达高于腹水中无肿瘤细胞者,差异具有统计学意义(x2=4.578,P<0.05;x2=13.445,P<0.05).结论 与卵巢良性肿瘤及正常卵巢组织相比,URG4在卵巢恶性上皮性肿瘤组织中表达增高;URG4阳性表达率与卵巢恶性上皮性肿瘤组织的临床分期、病理分级、淋巴结转移及腹水中癌细胞呈正相关,但与患者年龄及组织学类型相关无统计学意义.高表达的URG4可能在卵巢恶性上皮性肿瘤的发生、发展过程中起重要的作用.
目的 探討上調基因-4(URG4)在卵巢噁性上皮性腫瘤中的錶達及其與各臨床病理特徵之間的關繫.方法 採用免疫組化的方法檢測50例卵巢噁性上皮性腫瘤組織、20例卵巢良性腫瘤組織、20例正常卵巢組織標本中URG4的錶達情況,分析URG4的錶達與各臨床變量之間的關繫.結果 卵巢噁性上皮性腫瘤組織中URG4主要錶達于細胞漿中,呈現散在或瀰散的棕黃色顆粒.URG4在卵巢噁性上皮性腫瘤組織中的暘性錶達率(86%)高于卵巢良性腫瘤組織(40%)和正常卵巢組織(15%),差異具有統計學意義(x2=15.286,P<0.05;x2 =31.963,P<0.05).在不同年齡組及不同組織學類型的卵巢噁性上皮性腫瘤組織中,URG4的錶達差異無統計學意義(x2 =0.166,P>0.05;x2=0.603,P>0.05);隨著卵巢噁性上皮性腫瘤組織的臨床期彆、病理分級愈高,URG4的暘性錶達也愈彊,差異具有統計學意義(x2=8.449,P<0.05;x2=11.589,P<0.05),且有淋巴結轉移者URG4的錶達高于無淋巴結轉移者,腹水中腫瘤細胞暘性者URG4的錶達高于腹水中無腫瘤細胞者,差異具有統計學意義(x2=4.578,P<0.05;x2=13.445,P<0.05).結論 與卵巢良性腫瘤及正常卵巢組織相比,URG4在卵巢噁性上皮性腫瘤組織中錶達增高;URG4暘性錶達率與卵巢噁性上皮性腫瘤組織的臨床分期、病理分級、淋巴結轉移及腹水中癌細胞呈正相關,但與患者年齡及組織學類型相關無統計學意義.高錶達的URG4可能在卵巢噁性上皮性腫瘤的髮生、髮展過程中起重要的作用.
목적 탐토상조기인-4(URG4)재란소악성상피성종류중적표체급기여각림상병리특정지간적관계.방법 채용면역조화적방법검측50례란소악성상피성종류조직、20례란소량성종류조직、20례정상란소조직표본중URG4적표체정황,분석URG4적표체여각림상변량지간적관계.결과 란소악성상피성종류조직중URG4주요표체우세포장중,정현산재혹미산적종황색과립.URG4재란소악성상피성종류조직중적양성표체솔(86%)고우란소량성종류조직(40%)화정상란소조직(15%),차이구유통계학의의(x2=15.286,P<0.05;x2 =31.963,P<0.05).재불동년령조급불동조직학류형적란소악성상피성종류조직중,URG4적표체차이무통계학의의(x2 =0.166,P>0.05;x2=0.603,P>0.05);수착란소악성상피성종류조직적림상기별、병리분급유고,URG4적양성표체야유강,차이구유통계학의의(x2=8.449,P<0.05;x2=11.589,P<0.05),차유림파결전이자URG4적표체고우무림파결전이자,복수중종류세포양성자URG4적표체고우복수중무종류세포자,차이구유통계학의의(x2=4.578,P<0.05;x2=13.445,P<0.05).결론 여란소량성종류급정상란소조직상비,URG4재란소악성상피성종류조직중표체증고;URG4양성표체솔여란소악성상피성종류조직적림상분기、병리분급、림파결전이급복수중암세포정정상관,단여환자년령급조직학류형상관무통계학의의.고표체적URG4가능재란소악성상피성종류적발생、발전과정중기중요적작용.
Objective To investigate the expression of URG4 in epithelial ovarian carcinoma and the clinicopathological significance.Methods Immunohistochemical method was used to detect the expression of URG4 in 50 cases of epithelial ovarian carcinoma, 20 cases of benign ovarian tumor tissues and 20 cases of normal ovarian tissues.We analyzed the relationship between the expression of URG4 and clinical variables.Results In epithelial ovarian carcinoma, URG4-positive staining was shown as scattered or diffuse brown particles in cytoplasm.The expression rate of URG4 in 50 cases of epithelial ovarian carcinoma was 86% , which is significantly higher than that in 20 cases of benign overian tumor (40% , x2 =15.286, P <0.05) and 20 cases of normal ovarian tissue (15% , x2 =31.963, P < 0.05).In different age groups and different histological types of epithelial ovarian cancer tissues, the differences in the expression of URG4 were not statistically significant (x2 =0.166, P > 0.05 and x2 =0.603, P > 0.05, respectively).With in creases in clinical stage and the pathological grade of epithelial ovarian carcinoma tissues, the expression of URG4 became stronger, and the differences were significant (x2 =8.449, P<0.05;x2 =11.589, P <0.05).Moreover, the expression of URG4 in the patients with lymph node metastasis and with ascetic tumor cells was significantly higher than those without (x2 =4.578, P<0.05 and x2 =13.445, P <0.05, respectively).Conclusion Compared with benign ovarian tumors and normal ovarian tissues, the URG4 was over-expressed in epithelial ovarian carcinoma.In epithelial ovarian carcinoma, the expression of URG4 was positively correlated with clinical stage, pathological grade, lymphatic-metastasis and ascetic tumor cells, however, it had no correlation with age and histological type.Thus the overexpression of URG4 may play an important role in the occurrence and development of epithelial ovarian carcinoma.