国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
International Journal of Genetics
2015年
5期
249-253
,共5页
A-NHEJ%染色体易位%端粒融合%V(D)J重排%类别转换重组%肿瘤
A-NHEJ%染色體易位%耑粒融閤%V(D)J重排%類彆轉換重組%腫瘤
A-NHEJ%염색체역위%단립융합%V(D)J중배%유별전환중조%종류
A-NHEJ%Chromosomal translocation%Telomere fusion%V(D)J rearrangement%Class switch rearrangement%Tumor
DNA双链断裂(DNA double strand breaks,DSBs)是诸多DNA损伤类型中对基因组的完整性、稳定性影响最严重的一种损伤形式.选择性非同源末端连接(alternative nonhomologous end joining,A-NHEJ)是最近研究新发现的一种不依赖Ku蛋白的DSBs修复途径,由于它是一种易错的修复方式,因此能引起基因组不稳定甚至肿瘤发生.本文综述了A-NHEJ的发现以及其修复过程和特点,并介绍了A-NHEJ在染色体易位、端粒融合、V(D)J重排和类别转换重组中的DSBs修复作用.
DNA雙鏈斷裂(DNA double strand breaks,DSBs)是諸多DNA損傷類型中對基因組的完整性、穩定性影響最嚴重的一種損傷形式.選擇性非同源末耑連接(alternative nonhomologous end joining,A-NHEJ)是最近研究新髮現的一種不依賴Ku蛋白的DSBs脩複途徑,由于它是一種易錯的脩複方式,因此能引起基因組不穩定甚至腫瘤髮生.本文綜述瞭A-NHEJ的髮現以及其脩複過程和特點,併介紹瞭A-NHEJ在染色體易位、耑粒融閤、V(D)J重排和類彆轉換重組中的DSBs脩複作用.
DNA쌍련단렬(DNA double strand breaks,DSBs)시제다DNA손상류형중대기인조적완정성、은정성영향최엄중적일충손상형식.선택성비동원말단련접(alternative nonhomologous end joining,A-NHEJ)시최근연구신발현적일충불의뢰Ku단백적DSBs수복도경,유우타시일충역착적수복방식,인차능인기기인조불은정심지종류발생.본문종술료A-NHEJ적발현이급기수복과정화특점,병개소료A-NHEJ재염색체역위、단립융합、V(D)J중배화유별전환중조중적DSBs수복작용.
DNA double-strand breaks (DSBs) are the most severe damage of many types of DNA lesions that affect the genomic integrity and stability.Recently, a new Ku-independent DSBs repair pathway, alternative non-homologous end joining (A-NHEJ) , has been discovered, which is an errorprone repair pathway and thus may lead to genomic instability and even tumorigenesis.This review summarizes the discovery, repair process and characteristics of A-NHEJ, and also introduces theDSBs repair role of A-NHEJ in the process of chromosomal translocation, telomere fusion, V(D)J rearrangement and class switch recombination.
