非同源末端连接基因多态性与肿瘤相关性研究进展
비동원말단련접기인다태성여종류상관성연구진전
Progress of the association between polymorphism of non-homology end joining associated genes and cancer
  • 万方数据
    国际遗传学杂志 국제유전학잡지
    International Journal of Genetics
    2015年 5期 259-265 ,共7页

    王春涛%李秋炎%徐丽丹%乔远东%傅松滨

    왕춘도%리추염%서려단%교원동%부송빈

    非同源末端连接%双链断裂%基因多态性%肿瘤%关联 非同源末耑連接%雙鏈斷裂%基因多態性%腫瘤%關聯
    비동원말단련접%쌍련단렬%기인다태성%종류%관련
    NHEJ%DSBs%Gene polymorphism%Cancer%Association
    非同源末端连接为DNA双链断裂损伤的主要修复途径,通路相关基因在双链断裂的修复过程中的作用已经阐明.非同源末端连接基因的变异会影响其修复能力,导致基因组的不稳定进而引起肿瘤的发生,国内外已有大量关于此方面的病例研究和报道.此文主要就非同源末端连接基因多态性在肿瘤中的研究进展作一综述.
    비동원말단련접위DNA쌍련단렬손상적주요수복도경,통로상관기인재쌍련단렬적수복과정중적작용이경천명.비동원말단련접기인적변이회영향기수복능력,도치기인조적불은정진이인기종류적발생,국내외이유대량관우차방면적병례연구화보도.차문주요취비동원말단련접기인다태성재종류중적연구진전작일종술.
    Non-homology end joining (NHEJ) is the main repair pathway for double-strand breaks (DSBs) and the function of NHEJ-associated genes has been explored in the repair process of DSBs.Previous researches and case reports showed that the variation of NHEJ-associated genes can induce genome instability and the development of cancers by affecting the repair capability of DSBs.Herein, we review the progress on polymorphism of NHEJ associated genes in cancers.
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