CAJ | 학술논문

宿主遗传背景是导致人类免疫缺陷病毒(HIV)感染后不同个体间表型差异的主要因素之一.许多研究表明,APOBEC3 G、LEDGF/p75和SAMHD1在HIV-1复制周期中起到重要作用.其中,APOBEC3G具有广谱的抗逆转录病毒活性,可以有效的抑制HIV-1的复制;LEDGF/p75可以与整合酶结合,促进HIV-1整合到宿主基因组中;SAMHD1具有脱氧核苷三磷酸酶(dNTP ase)活性和核酸外切酶(RNase)活性,起到抑制病毒复制的作用.本文将对上述蛋白编码基因APOBEC3 G、PSIP1和SAMHD1基因多态性与HIV-1易感性和AIDS的相关性进展作一综述.
숙주유전배경시도치인류면역결함병독(HIV)감염후불동개체간표형차이적주요인소지일.허다연구표명,APOBEC3 G、LEDGF/p75화SAMHD1재HIV-1복제주기중기도중요작용.기중,APOBEC3G구유엄보적항역전록병독활성,가이유효적억제HIV-1적복제;LEDGF/p75가이여정합매결합,촉진HIV-1정합도숙주기인조중;SAMHD1구유탈양핵감삼린산매(dNTP ase)활성화핵산외절매(RNase)활성,기도억제병독복제적작용.본문장대상술단백편마기인APOBEC3 G、PSIP1화SAMHD1기인다태성여HIV-1역감성화AIDS적상관성진전작일종술.
The host genetic background is one of the major factors causing different phenotype between individuals after HIV-1 infection.Many studies found thatAPOBEC3 G, LEDGF/p75, and SAMHD1 play an important role in HIV-1 replication cycle.APOBEC3G has a broad antiviral activity,LEDGF/p75 can tether HIV-1 to the chromosome through interacting with integrase, and SAMHD1 can inhibit HIV-1 replication by its dNTPase and RNase activities.In this review, we summarize the research progress in the polymorphisms of APOBEC3 G, PSIP1 and SAMHD1 genes that encode the aforementioned proteins, their susceptibility to HIV-1 infection and association with AIDS.