CAJ | 학술논문

异柠檬酸脱氢酶1(IDH1)存在于细胞质和过氧化物酶体中,是三羧酸循环中的关键限速酶.近年来研究发现IDH1突变存在于多数胶质瘤中,其代谢产生的大量2-羟戊二酸可能作为潜在致癌物参与胶质瘤的发生,同时与患者预后的改善密切相关.IDH1突变有望作为新型基因标志指导临床胶质瘤的治疗.
이저몽산탈경매1(IDH1)존재우세포질화과양화물매체중,시삼최산순배중적관건한속매.근년래연구발현IDH1돌변존재우다수효질류중,기대사산생적대량2-간무이산가능작위잠재치암물삼여효질류적발생,동시여환자예후적개선밀절상관.IDH1돌변유망작위신형기인표지지도림상효질류적치료.
Isocitrate dehydrogenase 1 (IDH1), a key rate-limiting enzyme in tricarboxylic acid cycle,is found within the cytoplasm and peroxisomes.In recent years, IDH1 mutation is discovered in most gliomaand its large scale metabolites, 2-hydroxyglutarate, may be involved in tumor as potential carcinogens, and isshown to be closely related to better patients' survival as well.IDH1 mutation is anticipated to be a novel genet-ic biomarker which will guide the treatments of clinical glioma.