CAJ | 학술논문

目的观察复方谷氨酰胺在胃癌术后辅助治疗中的临床疗效.方法将63例胃癌根治术后的患者采用随机数字表法随机分为试验组和对照组,试验组32例,给予三维适形放疗同步卡培他滨单药方案化疗,同时口服复方谷氨酰胺肠溶胶囊.对照组31例,仅给予同步放化疗.结果试验组生命质量评分为良好和较好者分别占40.6％和34.4％,明显高于对照组的16.1％和12.9％,差异有统计学意义(x2=4.63,P=0.03x2 =4.00,P=0.04).试验组的恶心、呕吐和腹痛、腹泻的发生率分别为31.3％和37.5％,明显低于对照组的61.3％和64.5％,差异有统计学意义(x2=5.72,P=0.02;x2=4.60,P=0.03).试验组的胃肠道不良反应主要为Ⅰ度和Ⅱ度,未出现Ⅲ、Ⅳ度不良反应.试验组比对照组应用止泻药(21.9％:48.4％)及止痛药(15.6％:38.7％)的比例明显减少(x2=4.87,P=0.03;x2=4.26,P=0.04).结论胃癌术后辅助放化疗患者补充复方谷氨酰胺能够改善患者生命质量,降低放化疗引起的胃肠道不良反应,提高患者的治疗依从性,从而顺利完成治疗.
목적 관찰복방곡안선알재위암술후보조치료중적림상료효.방법 장63례위암근치술후적환자채용수궤수자표법수궤분위시험조화대조조,시험조32례,급여삼유괄형방료동보잡배타빈단약방안화료,동시구복복방곡안선알장용효낭.대조조31례,부급여동보방화료.결과 시험조생명질량평분위량호화교호자분별점40.6％화34.4％,명현고우대조조적16.1％화12.9％,차이유통계학의의(x2=4.63,P=0.03x2 =4.00,P=0.04).시험조적악심、구토화복통、복사적발생솔분별위31.3％화37.5％,명현저우대조조적61.3％화64.5％,차이유통계학의의(x2=5.72,P=0.02;x2=4.60,P=0.03).시험조적위장도불량반응주요위Ⅰ도화Ⅱ도,미출현Ⅲ、Ⅳ도불량반응.시험조비대조조응용지사약(21.9％:48.4％)급지통약(15.6％:38.7％)적비례명현감소(x2=4.87,P=0.03;x2=4.26,P=0.04).결론 위암술후보조방화료환자보충복방곡안선알능구개선환자생명질량,강저방화료인기적위장도불량반응,제고환자적치료의종성,종이순리완성치료.
Objective To evaluate the clinical effect of compound glutamine in the adjuvant treatment after radical surgery of gastric cancer.Methods A total of 63 cases with gastric cancer after radical resection were randomly divided into treatment group and control group, according to random number table.32 patients in treatment group received simultaneous three-dimensional conformal radiotherapy with capecitabine monotherapy regimen, while oral administration of compound glutamine enteric-coated capsules.31 cases in control group only received chemoradiotherapy.Results In treatment group, the quality of life score for the excellent and good accounted for 40.6％ and 34.4％, significantly higher than 16.1％ and 12.9％ in control group respectively (x2 =4.63, P =0.03;x2 =4.00, P =0.04).The incidence of nausea and vomiting, abdominal pain and diarrhea in treatment group respectively were 31.3％ and 37.5％ , significantly less than 61.3％ and 64.5％ in control group with statistical significance (x2 =5.72, P =0.02;x2 =4.60, P =0.03).The incidence of gastrointestinal reactions in treatment group were mainly Ⅰ and Ⅱ degrees, and Ⅲ-Ⅳ degree of gastrointestinal reactions were not appear.While the antidiarrheal drugs (21.9％ vs.48.4％) and analgesics drugs (15.6％ vs.38.7％) in the treatment group were significantly reduced compared with the control group (x2 =4.87, P =0.03;x2 =4.26, P =0.04).Conclusion By administration of compound glutamine in the course of adjuvant chemotherapy after radical surgery of gastric cancer can improve the quality of life, reduce chemotherapy-induced gastrointestinal side effects, improve treatment compliance, and successfully complete the treatment.