国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
Journal of International Oncology
2015年
11期
828-831
,共4页
子宫内膜肿瘤%预后%免疫组织化学%Yes相关蛋白
子宮內膜腫瘤%預後%免疫組織化學%Yes相關蛋白
자궁내막종류%예후%면역조직화학%Yes상관단백
Endometrial neoplasms%Prognosis%Immunohistochemistry%Yes-associated protein
目的 探讨Yes相关蛋白(YAP)在子宫内膜癌中的表达及其临床病理意义.方法 免疫组织化学MaxVisionTM法检测289例子宫内膜癌患者组织中YAP表达水平,分析其与患者临床病理特征及预后的关系.结果 YAP在Ⅱ型子宫内膜癌中的表达率高于Ⅰ型子宫内膜癌(87.0％:55.1％ ,x2=16.340,P＜0.001).在Ⅰ型子宫内膜癌中,YAP在组织学分级G1中的表达率为51.6％,低于G2-G3中的表达率80.0％ (x2 =8.549,P =0.005).YAP表达与绝经状态(x2=0.045,P=0.831)、FIGO分期(x2=0.976,P=0.323)、淋巴血管间隙浸润(x2=0.000,P=1.000)、淋巴结转移(x2=0.976,P =0.323)和ER状态(x2=3.318,P=0.069)无关;在Ⅱ型子宫内膜癌中,YAP表达与绝经状态(x2=0.305,P=0.581)、FIGO分期(x2=2.395,P=0.122)、淋巴血管间隙浸润(x2=1.441,P=0.230)、淋巴结转移(x2=1.351,P=0.245)和ER状态(x2=0.000,P=1.000)无关.在Ⅰ型子宫内膜癌中,Log-rank检验分析显示高表达YAP的患者整体生存率较低(x2=14.023,P＜0.001),但不是独立的预后因子.结论 YAP在子宫内膜癌中具有较高的表达率.在Ⅰ型子宫内膜癌中,YAP表达与组织学分级及预后正相关.
目的 探討Yes相關蛋白(YAP)在子宮內膜癌中的錶達及其臨床病理意義.方法 免疫組織化學MaxVisionTM法檢測289例子宮內膜癌患者組織中YAP錶達水平,分析其與患者臨床病理特徵及預後的關繫.結果 YAP在Ⅱ型子宮內膜癌中的錶達率高于Ⅰ型子宮內膜癌(87.0％:55.1％ ,x2=16.340,P＜0.001).在Ⅰ型子宮內膜癌中,YAP在組織學分級G1中的錶達率為51.6％,低于G2-G3中的錶達率80.0％ (x2 =8.549,P =0.005).YAP錶達與絕經狀態(x2=0.045,P=0.831)、FIGO分期(x2=0.976,P=0.323)、淋巴血管間隙浸潤(x2=0.000,P=1.000)、淋巴結轉移(x2=0.976,P =0.323)和ER狀態(x2=3.318,P=0.069)無關;在Ⅱ型子宮內膜癌中,YAP錶達與絕經狀態(x2=0.305,P=0.581)、FIGO分期(x2=2.395,P=0.122)、淋巴血管間隙浸潤(x2=1.441,P=0.230)、淋巴結轉移(x2=1.351,P=0.245)和ER狀態(x2=0.000,P=1.000)無關.在Ⅰ型子宮內膜癌中,Log-rank檢驗分析顯示高錶達YAP的患者整體生存率較低(x2=14.023,P＜0.001),但不是獨立的預後因子.結論 YAP在子宮內膜癌中具有較高的錶達率.在Ⅰ型子宮內膜癌中,YAP錶達與組織學分級及預後正相關.
목적 탐토Yes상관단백(YAP)재자궁내막암중적표체급기림상병리의의.방법 면역조직화학MaxVisionTM법검측289례자궁내막암환자조직중YAP표체수평,분석기여환자림상병리특정급예후적관계.결과 YAP재Ⅱ형자궁내막암중적표체솔고우Ⅰ형자궁내막암(87.0％:55.1％ ,x2=16.340,P＜0.001).재Ⅰ형자궁내막암중,YAP재조직학분급G1중적표체솔위51.6％,저우G2-G3중적표체솔80.0％ (x2 =8.549,P =0.005).YAP표체여절경상태(x2=0.045,P=0.831)、FIGO분기(x2=0.976,P=0.323)、림파혈관간극침윤(x2=0.000,P=1.000)、림파결전이(x2=0.976,P =0.323)화ER상태(x2=3.318,P=0.069)무관;재Ⅱ형자궁내막암중,YAP표체여절경상태(x2=0.305,P=0.581)、FIGO분기(x2=2.395,P=0.122)、림파혈관간극침윤(x2=1.441,P=0.230)、림파결전이(x2=1.351,P=0.245)화ER상태(x2=0.000,P=1.000)무관.재Ⅰ형자궁내막암중,Log-rank검험분석현시고표체YAP적환자정체생존솔교저(x2=14.023,P＜0.001),단불시독립적예후인자.결론 YAP재자궁내막암중구유교고적표체솔.재Ⅰ형자궁내막암중,YAP표체여조직학분급급예후정상관.
Objective To study the expression of Yes-associated protein(YAP) in endometrial cancer and its clinical pathological significance.Methods Immunohistochemieal MaxVisionTM method was used to detect the expression of YAP in 289 cases of endometrial cancer, and its relationship with clinical pathological features and prognosis were analyzed.Results The expression rate of YAP in type Ⅱ endometrial cancer was higher than that in typeⅠendometrial cancer (87.0％ vs.55.1％, x2 =16.340, P ＜ 0.001).In typeⅠendometrial cancer, the expression rate of YAP in G1 cases was lower than that in G2-G3 cases (51.6％ vs.80.0％, x2 =8.549, P =0.005), not associated with menopausal status (x2 =0.045, P =0.831), FIGO stage (x2 =0.976, P =0.323), lymph vascular space invasion (x2 =0.000, P =1.000), lymph node metastasis (x2 =0.976, P =0.323) and ER status (x2 =3.318, P =0.069).In typeⅡendometrial cancer, the expression of YAP was not significantly associated with menopausal status (x2 =0.305, P =0.581), FIGO stage (x2 =2.395, P =0.122), lymph vascular space invasion (x2 =1.441, P =0.230), lymph node metastasis (x2 =1.351, P =0.245) and ER status (x2 =0.000, P =1.000).Log-rank test analysis showed that YAP high-expression was associated with a significantly worse overall survival in typeⅠ endometrial cancer (x2 =14.023, P ＜ 0.001), but YAP expression was not an independent prognostic factor.Conclusion YAP shows high expression in endometrial cancer.It is associated with histological grade and prognosis of typeⅠ endometrial cancer.
