中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
Chinese Journal of Experimental Ophthalmology
2015年
11期
1048-1051
,共4页
哺乳动物雷帕霉素靶蛋白%信号通路%雷帕霉素%眼科疾病
哺乳動物雷帕黴素靶蛋白%信號通路%雷帕黴素%眼科疾病
포유동물뢰파매소파단백%신호통로%뢰파매소%안과질병
Mammalian target of rapamycin%Signaling pathway%Rapamycin%Ophthalmic diseases
哺乳动物雷帕霉素靶蛋白(mTOR)是一种高度进化保守的蛋白激酶,控制细胞生长、生长因子和细胞能量的形成,参与营养、新陈代谢及老化过程,近年发现mTOR信号通路与细胞生长、调控蛋白质合成代谢密切相关,已成为肿瘤形成、代谢紊乱、神经系统疾病和炎症等疾病的重要通路.就mTOR及通路介导的眼科疾病进行综述.
哺乳動物雷帕黴素靶蛋白(mTOR)是一種高度進化保守的蛋白激酶,控製細胞生長、生長因子和細胞能量的形成,參與營養、新陳代謝及老化過程,近年髮現mTOR信號通路與細胞生長、調控蛋白質閤成代謝密切相關,已成為腫瘤形成、代謝紊亂、神經繫統疾病和炎癥等疾病的重要通路.就mTOR及通路介導的眼科疾病進行綜述.
포유동물뢰파매소파단백(mTOR)시일충고도진화보수적단백격매,공제세포생장、생장인자화세포능량적형성,삼여영양、신진대사급노화과정,근년발현mTOR신호통로여세포생장、조공단백질합성대사밀절상관,이성위종류형성、대사문란、신경계통질병화염증등질병적중요통로.취mTOR급통로개도적안과질병진행종술.
Mammalian target of rapamycin (mTOR) is a highly evolutionary conserved protein kinase and plays a critical role in the regulation of cell growth, growth factors and cell energy, and thus contributes to the formation of nutrition, metabolism and aging processes.Recent studies found that mTOR signaling pathway is associated with cell cycle, protein synthesis and metabolism, and it is an important pathway of diseases such as development of tumor,metabolic disorders,nervous system disease and inflammation.The relationship between mTOR signaling pathway and ophthalmic diseases was reviewed in this article.
