CAJ | 학술논문

叠氮烷基硫醇是一种含有双官能团的功能型分子,基于点击化学,可用于生物及化学传感器金表面的功能化修饰.目前已有的合成方法步骤繁多,反应条件苛刻且多使用有毒有害的试剂,不利于大量合成.本文以溴化十一醇为原料,使用叠氮化钠、硫脲经三步反应合成叠氮十一烷基硫醇,其结构经1H NMR与FT-IR表征,产率达70%.本文研究反应步骤简单,条件温和,使有机合成得到了优化,为叠氮烷基硫醇在生化传感器中多功能化"点击化学"修饰的广泛应用奠定了基础.
첩담완기류순시일충함유쌍관능단적공능형분자,기우점격화학,가용우생물급화학전감기금표면적공능화수식.목전이유적합성방법보취번다,반응조건가각차다사용유독유해적시제,불리우대량합성.본문이추화십일순위원료,사용첩담화납、류뇨경삼보반응합성첩담십일완기류순,기결구경1H NMR여FT-IR표정,산솔체70%.본문연구반응보취간단,조건온화,사유궤합성득도료우화,위첩담완기류순재생화전감기중다공능화"점격화학"수식적엄범응용전정료기출.
Azido-thiol is a bifunctional molecule with thiol and azide groups,which has always been used for gold-surface modification of functionalized chem/biosensors by click chemistry. The synthesis of aizdo-thiols always requires many complicated processes with synthetically harsh conditions. Furthermore,the utilization of toxic reagents is not practical to large-scale production. Herein,a new method of only three steps was demonstrated to synthesize 11-azido-undecanthiol using 11-bromo-1-undecanol,sodium azide and thiourea. The product and intermediates were characterized by 1H NMR and FT-IR;the yield is nearly 70%. The proposed research provides a simpler way to synthesize azido-thiol with mild synthetically conditions and optimum processes,which will be easily implemented in chem/biosensors due to multifunctional "click-chemistry" modification.