CAJ | 학술논문

目的评价尿酸对成年人前期糖尿病发生的预测价值.方法研究对象来自天津医科大学总医院体检中心.队列研究人数为30 910人,其中男性占47.9%,平均年龄为35.4岁,总共随访83 894人年(中位数为2.7人年).基线和随访期检测所有相关变量,包括血清尿酸浓度和空腹血糖等.血清尿酸五分位水平与前期糖尿病发病率的关系通过Cox比例风险回归模型进行统计分析.结果前期糖尿病发病率为55人/1 000人年.调整了潜在的混杂因素后随着血清尿酸浓度的增高,前期糖尿病发生的风险比(95%可信区间)分别为1.00,1.04 (0.93,1.15),1.07 (0.95,1.19),1.13 (1.01,1.28)和1.15 (1.02,1.30)(趋势性P值=0.01).结论在成年人群中血清尿酸水平能够预测前期糖尿病的发生风险.
목적 평개뇨산대성년인전기당뇨병발생적예측개치.방법 연구대상래자천진의과대학총의원체검중심.대렬연구인수위30 910인,기중남성점47.9%,평균년령위35.4세,총공수방83 894인년(중위수위2.7인년).기선화수방기검측소유상관변량,포괄혈청뇨산농도화공복혈당등.혈청뇨산오분위수평여전기당뇨병발병솔적관계통과Cox비례풍험회귀모형진행통계분석.결과 전기당뇨병발병솔위55인/1 000인년.조정료잠재적혼잡인소후수착혈청뇨산농도적증고,전기당뇨병발생적풍험비(95%가신구간)분별위1.00,1.04 (0.93,1.15),1.07 (0.95,1.19),1.13 (1.01,1.28)화1.15 (1.02,1.30)(추세성P치=0.01).결론 재성년인군중혈청뇨산수평능구예측전기당뇨병적발생풍험.
Objective To evaluate whether the serum uric acid (SUA) levels are related to development of prediabetes. Methods This was a 6-year cohort study, subjects were recruited from Tianjin Medical University General Hospital Health Management Center. A prospective assessment (n=30 910) was performed. Subjects without a history of prediabetes were followed up for 6 years (with a median follow-up of 2.7 person-years). All relevant variables including SUA concentrations, and fasting plasma glucose were assessed at baseline and yearly during the follow-up. Prediabetes was defined in accordance with the American Diabetes Association criteria of 2014. Multivariate-adjusted Cox proportional hazards regression models were fitted to assess relationships between the quintiles of baseline SUA and the incidence of prediabetes. Results The incidence of prediabetes was 55 per 1 000 person-years. In comparison with subjects in the lowest quintile, the odds ratios and hazard ratio (95%confidence interval) of higher quintile of SUA were 1.04 (0.93, 1.15), 1.07 (0.95, 1.19), 1.13 (1.01, 1.28) and 1.15 (1.02, 1.30) (P for trend=0.01), respectively, after adjusting for potential confounders. Conclusion SUA levels predicted an increased risk of prediabetes in adults.