医学检验与临床
醫學檢驗與臨床
의학검험여림상
Medical Laboratory Science and Clinics
2015年
5期
3-5
,共3页
血清缺血修饰白蛋白%超敏肌钙蛋白T%心肌缺血%诊断价值
血清缺血脩飾白蛋白%超敏肌鈣蛋白T%心肌缺血%診斷價值
혈청결혈수식백단백%초민기개단백T%심기결혈%진단개치
Serum ischemia modified albumin%High sensitivity troponin T%Myocardial ischemia%Diagnosis value
目的：研究血清缺血修饰白蛋白(1MA)及超敏肌钙蛋白T(hs-TnT)水平对心肌缺血引发相关疾病的临床诊断价值。方法：对我院2014年1月至2015年3月因胸痛、胸闷或急性心梗发作就诊患者150例，分别于入院2h、6h、12h、24h取样行1MA和hs-TnT检测，并根据出院诊断分组，观察各组患者不同时间段1MA和hs-TnT水平，通过回顾性分析研究1MA和hs-TnT在心肌缺血疾病诊断中的敏感性和特异性。结果：入院2h、6h，UA组、NSTEMI组、STEMI组IMA水平低于NICP组，组间比较差异明显（P＜0.05）；STEMI组IMA水平明显低于UA组、NSTEMI组（P＜0.05），入院6h、12h、24hUA组、NSTEMI组、STEMI组hs-TnT水平明显高于NICP组（P＜0.05）， NSTEMI组、STEMI组hs-TnT水平明显高于UA组（P＜0.05）。IMA单独诊断ACS的敏感性为70.6%，特异性为51.7%；IMA、hs-TnT联合诊断心肌缺血的敏感性和特异性分别为94.1%和72.9%，联合诊断敏感性和特异性均高于单独诊断（P＜0.05）。结论：联合检测IMA和hs-TnT对诊断心肌缺血引发的心血管疾病有较高的临床价值，同时两项指标联合应用可反映心肌缺血的发展进程，评估疾病严重程度，对指导治疗和预后的判断有一定作用。
目的：研究血清缺血脩飾白蛋白(1MA)及超敏肌鈣蛋白T(hs-TnT)水平對心肌缺血引髮相關疾病的臨床診斷價值。方法：對我院2014年1月至2015年3月因胸痛、胸悶或急性心梗髮作就診患者150例，分彆于入院2h、6h、12h、24h取樣行1MA和hs-TnT檢測，併根據齣院診斷分組，觀察各組患者不同時間段1MA和hs-TnT水平，通過迴顧性分析研究1MA和hs-TnT在心肌缺血疾病診斷中的敏感性和特異性。結果：入院2h、6h，UA組、NSTEMI組、STEMI組IMA水平低于NICP組，組間比較差異明顯（P＜0.05）；STEMI組IMA水平明顯低于UA組、NSTEMI組（P＜0.05），入院6h、12h、24hUA組、NSTEMI組、STEMI組hs-TnT水平明顯高于NICP組（P＜0.05）， NSTEMI組、STEMI組hs-TnT水平明顯高于UA組（P＜0.05）。IMA單獨診斷ACS的敏感性為70.6%，特異性為51.7%；IMA、hs-TnT聯閤診斷心肌缺血的敏感性和特異性分彆為94.1%和72.9%，聯閤診斷敏感性和特異性均高于單獨診斷（P＜0.05）。結論：聯閤檢測IMA和hs-TnT對診斷心肌缺血引髮的心血管疾病有較高的臨床價值，同時兩項指標聯閤應用可反映心肌缺血的髮展進程，評估疾病嚴重程度，對指導治療和預後的判斷有一定作用。
목적：연구혈청결혈수식백단백(1MA)급초민기개단백T(hs-TnT)수평대심기결혈인발상관질병적림상진단개치。방법：대아원2014년1월지2015년3월인흉통、흉민혹급성심경발작취진환자150례，분별우입원2h、6h、12h、24h취양행1MA화hs-TnT검측，병근거출원진단분조，관찰각조환자불동시간단1MA화hs-TnT수평，통과회고성분석연구1MA화hs-TnT재심기결혈질병진단중적민감성화특이성。결과：입원2h、6h，UA조、NSTEMI조、STEMI조IMA수평저우NICP조，조간비교차이명현（P＜0.05）；STEMI조IMA수평명현저우UA조、NSTEMI조（P＜0.05），입원6h、12h、24hUA조、NSTEMI조、STEMI조hs-TnT수평명현고우NICP조（P＜0.05）， NSTEMI조、STEMI조hs-TnT수평명현고우UA조（P＜0.05）。IMA단독진단ACS적민감성위70.6%，특이성위51.7%；IMA、hs-TnT연합진단심기결혈적민감성화특이성분별위94.1%화72.9%，연합진단민감성화특이성균고우단독진단（P＜0.05）。결론：연합검측IMA화hs-TnT대진단심기결혈인발적심혈관질병유교고적림상개치，동시량항지표연합응용가반영심기결혈적발전진정，평고질병엄중정도，대지도치료화예후적판단유일정작용。
Objective:To study the clinical diagnostic value of serum ischemia modified albumin (1MA) and serum troponin T (hs-TnT) in the diagnosis of myocardial ischemia related diseases.Methods:In our hospital in January 2014 to 2015 March because of chest pain, chest tightness or acute myocardial infarction attack patients with 150 cases, respectively at admission for 2h, 6h, 12h, 24h sample 1mA and HS TNT detection and according to the discharge diagnosis group observed patients in each group at different time 1mA and HS TNT level, sensitivity and specificity in diagnosis of myocardial ischemia disease research 1mA and HS TNT were retrospectively analyzed.Results: Admission at 2h, 6h, UA, NSTEMI and STEMI group ima levels lower than group nicp, inter group significant differences (P< 0.05); IMA level in STEMI group was significantly lower than that of the UA and NSTEMI group (P< 0.05). Admission 6h, 12h, 24hUA, NSTEMI and STEMI group HS TNT level was significantly higher than that of nicp group (P< 0.05), NSTEMI and STEMI group HS TNT level was significantly higher than that of the UA group (P< 0.05). Ima alone, the diagnostic sensitivity of ACS was 70.6%, specificity was 51.7%; HS TNT and ima combined diagnosis sensitivity and specificity of myocardial ischemia were 94.1% and 72.9%, combined diagnostic sensitivity and specificity were higher than single diagnosis (P< 0.05).Conclusions:Clinical value of joint detection of IMA and HS TNT for the diagnosis of myocardial ischemia caused by cardiovascular diseases is high. At the same time, combined application of the two parameters can reflect the development of myocardial ischemia, to assess the severity of the disease, for the guidance of treatment and prognosis judgment have a role.
