CAJ | 학술논문

评价克癌素结肠定位包衣滴丸有效成分槲皮素在家兔体内的药代动力学和相对生物利用度．采用HPLC法测定受试制剂和参比制剂中健康家兔体内槲皮素的血药质量浓度，DAS2．1软件计算主要药代动力学参数．结果表明，槲皮素质量浓度在0．004～0．4μg／mL范围内具有良好的线性关系．包衣滴丸的体内吸收时滞为5 h左右，AUC仅为参比制剂的17．6％，其Cmax为参比制剂的75．6％，二者间均不具生物等效性．该口服结肠定位制剂符合pH敏感－时间控释双重机理，具有良好的靶向结肠定位效果．
평개극암소결장정위포의적환유효성분곡피소재가토체내적약대동역학화상대생물이용도．채용HPLC법측정수시제제화삼비제제중건강가토체내곡피소적혈약질량농도，DAS2．1연건계산주요약대동역학삼수．결과표명，곡피소질량농도재0．004～0．4μg／mL범위내구유량호적선성관계．포의적환적체내흡수시체위5 h좌우，AUC부위삼비제제적17．6％，기Cmax위삼비제제적75．6％，이자간균불구생물등효성．해구복결장정위제제부합pH민감－시간공석쌍중궤리，구유량호적파향결장정위효과．
To study the pharmacokinetics and absolute bioavailability of quercetin in rabbits . A HPLC method was developed for the determination of the experimental and contrastive cur-cumin in the healthy rabbit plasma .A good linear relationship was obtained in the range of 0.004~0.4 μg/mL.Tmax =5 h, AUC was 17.6% of the reference product , and Cmax was 75.6%of that.There was no bioequivalence between the experimental and reference prod-uct .The oral colon positioning preparation conforms to the dual mechanism of pH sensitive -controlled release time , and had good positioning to colon targeting effect .