CAJ | 학술논문

目的：探讨电针对急性心肌梗死大鼠心肌基质金属蛋白酶-2（MMP-2）、组织基质金属蛋白酶-2（TIMP-2）和缝隙连接蛋白43（Cx43）表达的影响。方法：结扎大鼠冠状动脉左前降支建立急性心肌梗死模型，SD大鼠随机分为正常组、模型组和电针组3组。记录各组大鼠心电图变化，以RT-PCR测定心肌组织中MMP-2、TIMP-2表达的变化，用免疫组化检测Cx43。结果：与模型组比较，电针组心电图有明显改善，TIMP-2、Cx43 MMP-2表达显著升高（P<0.05，P<0.01）。结论：电针内关、心俞通过调节MMP-2、TIMP-2的表达保护缺血梗死心肌组织，且有效对抗心律失常。
목적：탐토전침대급성심기경사대서심기기질금속단백매-2（MMP-2）、조직기질금속단백매-2（TIMP-2）화봉극련접단백43（Cx43）표체적영향。방법：결찰대서관상동맥좌전강지건립급성심기경사모형，SD대서수궤분위정상조、모형조화전침조3조。기록각조대서심전도변화，이RT-PCR측정심기조직중MMP-2、TIMP-2표체적변화，용면역조화검측Cx43。결과：여모형조비교，전침조심전도유명현개선，TIMP-2、Cx43 MMP-2표체현저승고（P<0.05，P<0.01）。결론：전침내관、심유통과조절MMP-2、TIMP-2적표체보호결혈경사심기조직，차유효대항심률실상。
Objective:To investigate the effects of electro-acupuncture at "Neiguan","Xinshu" on expression of MMP-2, TIMP-2 and Cx43 in rats with acute myocardial infarction (AMI). Methods:SD rats were randomly divided into normal group(N group),model group(AMI group)and electro-acupuncture group(E group). AMI rat models were induced by left anterior descending artery ligation. The change of electrocardiogram was recorded,expressions of MMP-2,TIMP-2 and Cx43 were detected in each group. Results:Compared with the AMI group,ECG has been significantly improved, expressions of TIMP-2 and Cx43 were increased in E group (P<0.05,P<0.01). The expression of MMP-2 in E group was higher than that in other groups (P<0.05). Conclusion:Electro-acupuncture at "Neiguan","Xinshu"can protect ischemic myocardial tissue by adjusting expression of MMP-2,TIMP-2. It has anti-arrhythmic effect.