CAJ | 학술논문

目的：调查分析黑龙江省健康青少年血清钙、磷和碱性磷酸酶水平，建立性别和年龄相关的参考范围。方法于2008年7月－2009年6月，从黑龙江省哈尔滨和牡丹江的市区、郊区随机抽取2101名9～18岁健康中小学生进行体检，测定血清钙、磷和碱性磷酸酶浓度。筛除离群数据个体后，共2091名受试者入选。考虑性别和年龄因素，建立相应的血清钙、磷和碱性磷酸酶的参考范围（ P2.5～P97.5）。结果描述了9～18岁青少年男性和女性血清钙、磷和碱性磷酸酶水平随年龄、性别的变化趋势。血清钙、磷和碱性磷酸酶水平与年龄呈明显的负相关，且男性高于女性（ P＜0.001）。全部人群的血清钙、磷和女性的碱性磷酸酶水平随年龄的增加而下降，而男性的13岁年龄组碱性磷酸酶水平最高，13岁前随年龄增加而增加，13岁后随年龄增加而降低。结论初步建立了黑龙江省健康青少年血清钙、磷和碱性磷酸酶的参考范围，对临床医生特别是儿科医生对上述指标的结果解释和临床干预具有很好的参考价值。
목적：조사분석흑룡강성건강청소년혈청개、린화감성린산매수평，건립성별화년령상관적삼고범위。방법우2008년7월－2009년6월，종흑룡강성합이빈화모단강적시구、교구수궤추취2101명9～18세건강중소학생진행체검，측정혈청개、린화감성린산매농도。사제리군수거개체후，공2091명수시자입선。고필성별화년령인소，건립상응적혈청개、린화감성린산매적삼고범위（ P2.5～P97.5）。결과묘술료9～18세청소년남성화녀성혈청개、린화감성린산매수평수년령、성별적변화추세。혈청개、린화감성린산매수평여년령정명현적부상관，차남성고우녀성（ P＜0.001）。전부인군적혈청개、린화녀성적감성린산매수평수년령적증가이하강，이남성적13세년령조감성린산매수평최고，13세전수년령증가이증가，13세후수년령증가이강저。결론초보건립료흑룡강성건강청소년혈청개、린화감성린산매적삼고범위，대림상의생특별시인과의생대상술지표적결과해석화림상간예구유흔호적삼고개치。
Objective To analyze the serum calcium , phosphate and alkaline phosphatase level among apparently healthy school children and adolescents in Heilongjiang Province and establish the reference intervals in different gender and different age groups .Methods Random sample of 2 101 primary and secondary school students from 9 to 18-year-old was collected from different district of Heilongjiang Province including Harbin and Mudanjiang from July 2008 to June 2009 .The fasting venous blood was collected and serum calcium , phosphate and alkaline phos-phatase concentration was measured as soon as possible .After screening outlier individual , a total of 2 091 subjects were enrolled.The reference intervals of serum calcium , phosphate and alkaline phosphatase for healthy school children and adolescents were established by gender and age ( P2.5 to P97.5 ) .Results The change tendency of serum calcium, phosphate and alkaline phosphatase with age and sex were presented .All these parameters had shown inverse relationship with age and were significantly higher in boys than girls (P<0.001).Serum calcium, phosphate of both sexes and serum alkaline phosphatase of girls declined progressively with age .However , the highest alkaline phosphatase level was seen at 13 years in boys.Alkaline phosphatase showed a positive correlation with age before 13 years of age , but after that alkaline phosphatase started to decline .Conclusions Reference in-tervals of serum calcium , phosphate and alkaline phosphatase for healthy school children and adolescents in Hei -longjiang Province in the age group of 9-18 years were presented , which supply good reference value for clinicians especially pediatricians to interpret the results of school children and adolescents and make decision .