山西中医学院学报
山西中醫學院學報
산서중의학원학보
Journal of Shanxi College of Traditional Chinese Medicine
2015年
4期
29-30
,共2页
程侯连%李宝霞%甄会贤%杜学勤
程侯連%李寶霞%甄會賢%杜學勤
정후련%리보하%견회현%두학근
醋氯芬酸%对乙酰氨基酚%联合用药%协同作用
醋氯芬痠%對乙酰氨基酚%聯閤用藥%協同作用
작록분산%대을선안기분%연합용약%협동작용
aceclofenac%paracetamol%drug combination%synergistic action
目的：研究醋氯芬酸和对乙酰氨基酚联合用药后镇痛抗炎作用。方法：采用小鼠热板法、小鼠醋酸扭体实验观察其抗炎、镇痛作用。结果：热板法实验可以确定醋氯芬酸与对乙酰氨基酚有明显协同作用，通过醋酸扭体实验，醋氯芬酸与对乙酰氨基酚剂量比例为1∶5时镇痛作用最大。结论：醋氯芬酸与对乙酰氨基酚配伍，其药效有明显协同作用。
目的：研究醋氯芬痠和對乙酰氨基酚聯閤用藥後鎮痛抗炎作用。方法：採用小鼠熱闆法、小鼠醋痠扭體實驗觀察其抗炎、鎮痛作用。結果：熱闆法實驗可以確定醋氯芬痠與對乙酰氨基酚有明顯協同作用，通過醋痠扭體實驗，醋氯芬痠與對乙酰氨基酚劑量比例為1∶5時鎮痛作用最大。結論：醋氯芬痠與對乙酰氨基酚配伍，其藥效有明顯協同作用。
목적：연구작록분산화대을선안기분연합용약후진통항염작용。방법：채용소서열판법、소서작산뉴체실험관찰기항염、진통작용。결과：열판법실험가이학정작록분산여대을선안기분유명현협동작용，통과작산뉴체실험，작록분산여대을선안기분제량비례위1∶5시진통작용최대。결론：작록분산여대을선안기분배오，기약효유명현협동작용。
Objective:To study on anti-inflammatory and analgesic effects of aceclofenac and paracetamol. Methods:Anti-inflammatory and analgesic effects were observed by mouse hot plate test and acetic acid stretching experiment. Results:Significant synergistic effect of aceclofenac combinated with paracetamol was determined by mouse hot plate test. The analgesic effects reached the maximum when the ratio of aceclofenac and paracetamol dose was 1∶5. Conclusion:Efficacy on compatibility of aceclofenac and paracetamol has obvious synergistic effect.
