山西中医学院学报
山西中醫學院學報
산서중의학원학보
Journal of Shanxi College of Traditional Chinese Medicine
2015年
4期
16-18
,共3页
心动过缓%炙桂枝%肉桂%普萘洛尔%Na+-K+-ATP酶
心動過緩%炙桂枝%肉桂%普萘洛爾%Na+-K+-ATP酶
심동과완%자계지%육계%보내락이%Na+-K+-ATP매
bradycardia%prepared cassia twig%cassia%propranolol%Na+-K+-ATPase
目的：比较炙桂枝与肉桂对普萘洛尔所致心动过缓大鼠心率及Na+-K+-ATP酶活性的影响，分析炙桂枝与肉桂在抗心动过缓中的作用机制及两者差异。方法：将70只大鼠随机分为炙桂枝组、炙桂枝模型组、肉桂组、肉桂模型组、空白组、普萘洛尔模型对照组，每组10只。连续给药7 d，以普萘洛尔造模，比较各组大鼠心率变化及Na+-K+-ATP酶活性。结果：炙桂枝组与肉桂组30 min心率减慢变化率较普萘洛尔模型对照组明显升高（P<0.01）；炙桂枝模型组、肉桂模型组Na+-K+-ATP酶活性较普萘洛尔模型对照组高（P<0.01）。结论：炙桂枝与肉桂均能显著提高普萘洛尔致心动过缓的大鼠的Na+-K+-ATP酶活性，以增加心率。
目的：比較炙桂枝與肉桂對普萘洛爾所緻心動過緩大鼠心率及Na+-K+-ATP酶活性的影響，分析炙桂枝與肉桂在抗心動過緩中的作用機製及兩者差異。方法：將70隻大鼠隨機分為炙桂枝組、炙桂枝模型組、肉桂組、肉桂模型組、空白組、普萘洛爾模型對照組，每組10隻。連續給藥7 d，以普萘洛爾造模，比較各組大鼠心率變化及Na+-K+-ATP酶活性。結果：炙桂枝組與肉桂組30 min心率減慢變化率較普萘洛爾模型對照組明顯升高（P<0.01）；炙桂枝模型組、肉桂模型組Na+-K+-ATP酶活性較普萘洛爾模型對照組高（P<0.01）。結論：炙桂枝與肉桂均能顯著提高普萘洛爾緻心動過緩的大鼠的Na+-K+-ATP酶活性，以增加心率。
목적：비교자계지여육계대보내락이소치심동과완대서심솔급Na+-K+-ATP매활성적영향，분석자계지여육계재항심동과완중적작용궤제급량자차이。방법：장70지대서수궤분위자계지조、자계지모형조、육계조、육계모형조、공백조、보내락이모형대조조，매조10지。련속급약7 d，이보내락이조모，비교각조대서심솔변화급Na+-K+-ATP매활성。결과：자계지조여육계조30 min심솔감만변화솔교보내락이모형대조조명현승고（P<0.01）；자계지모형조、육계모형조Na+-K+-ATP매활성교보내락이모형대조조고（P<0.01）。결론：자계지여육계균능현저제고보내락이치심동과완적대서적Na+-K+-ATP매활성，이증가심솔。
Objective:To study effect of prepared cassia twigs and cassia on Na +-K +-ATPase activity in rats with bradycardia caused by propranolol. Methods:70 rats were randomly divided into prepared cassia twig group,prepared cassia twig model group,cassia group,cassia model group,blank group,propranolol group and atropine group (n=10). Model rats were constructed by propranolol.7 d after treatment,heart rate and activity of Na+-K+-ATPase were observed. Results:Compared with propranolol group,the drop rate of 30 min heart rate was decreased in prepared cassia twig model group and cassia model group (P<0.01). The activity of Na+-K+-ATPase in prepared cassia twig model group and cassia model group was higher than that in propranolol group(P<0.05,P<0.01). Conclusion:Both prepared cassia twig and cassia can obviously increase the heart rate in bradycardia rats caused by propranolol through improving the activity of Na+-K+ATpase.
