CAJ | 학술논문

肝细胞癌是一种在微环境刺激因素作用下由肝细胞基因组积累的突变所导致的常见原发性肝癌。肿瘤微环境是一个动态系统，由肿瘤细胞、间质组织、细胞外基质、组织低氧及饮食、胃肠道微生物群落和微泡等组成，肝脏微环境在肝细胞癌发生，发展和治疗中起重要作用，研究肝细胞癌微环境可为发现肿瘤生成机制和肝细胞癌治疗新靶点提供新的借鉴。
간세포암시일충재미배경자격인소작용하유간세포기인조적루적돌변소도치적상견원발성간암。종류미배경시일개동태계통，유종류세포、간질조직、세포외기질、조직저양급음식、위장도미생물군락화미포등조성，간장미배경재간세포암발생，발전화치료중기중요작용，연구간세포암미배경가위발현종류생성궤제화간세포암치료신파점제공신적차감。
Hepatocellular carcinoma ( HCC) is a prevalent primary liver cancer that is driven by cumulative chan-ges in the hepatocyte genome which were influenced by the liver microenvironment .The tumor microenvironment is a dynamic system, including cancer cells, stroma, the extracellular matrix.tissue hypoxia, diet, gastrointestinal tract ( GIT) microflora and circulating microvesicles , The liver microenvironment plays a pivotal role in HCC tu-merigenesis , progression and therapeutic efficienry .The study of the HCC microenvironment will provide new in-sights into the mechanism of tumourigenesis and potential novel targets in the treatment of HCC .