CAJ | 학술논문

糖尿病性认知功能障碍是糖尿病的重要并发症之一。胰岛素通过MAPK和PI3-K／Akt信号通路对认知功能具有重要保护作用。胰岛素抵抗可导致tau蛋白的过度磷酸化，形成神经纤维节；可竞争性抑制胰岛素降解酶，减少β淀粉样蛋白的降解；增强氧化应激，破坏神经元结构和功能的完整性，从而损伤认知功能。
당뇨병성인지공능장애시당뇨병적중요병발증지일。이도소통과MAPK화PI3-K／Akt신호통로대인지공능구유중요보호작용。이도소저항가도치tau단백적과도린산화，형성신경섬유절；가경쟁성억제이도소강해매，감소β정분양단백적강해；증강양화응격，파배신경원결구화공능적완정성，종이손상인지공능。
Diabetic cognitive dysfunction is one of the important complications of diabetes mellitus .Insulin plays an important protective role in cognitive function through MAPK and PI 3-K/Akt signaling pathway .Insulin resistance may give rise to excessive tau protein phosphorylation , formation of neurofibrillary tangles inhibits insulin degrading enzyme , reduces the degradation of amyloid β;enhances oxidative stress , further damages the integrity of the neu-ronal structure and function and eventually leads to cognitive dysfunction .