CAJ | 학술논문

目的：探讨放射治疗对早期鼻咽癌患者骨导听阈的影响。方法收集2006年2月至2012年3月在我院治疗且资料完整的32例早期鼻咽癌患者，分别记录患者放疗前、放疗后1.5年及放疗后2年双耳0.5、1、2、4 kHz四个语言频率骨导听阈值及畸变产物耳声发射，并对记录的数据进行统计分析。结果患者双耳0.5、1、2、4 kHz四个语言频率骨导阈值放疗后1.5年及放疗后2年均高于放疗前，且三者差异有统计学意义(P<0.05)。放疗后1.5年及放疗后2年患者DPOAE检查未通过率增高，且差异有统计学意义(P<0.05)。结论放疗可以使早期鼻咽癌患者骨导阈值提高，对于鼻咽癌放疗患者应尽早积极防治，避免感音神经性听力损失。
목적：탐토방사치료대조기비인암환자골도은역적영향。방법수집2006년2월지2012년3월재아원치료차자료완정적32례조기비인암환자，분별기록환자방료전、방료후1.5년급방료후2년쌍이0.5、1、2、4 kHz사개어언빈솔골도은역치급기변산물이성발사，병대기록적수거진행통계분석。결과환자쌍이0.5、1、2、4 kHz사개어언빈솔골도역치방료후1.5년급방료후2년균고우방료전，차삼자차이유통계학의의(P<0.05)。방료후1.5년급방료후2년환자DPOAE검사미통과솔증고，차차이유통계학의의(P<0.05)。결론방료가이사조기비인암환자골도역치제고，대우비인암방료환자응진조적겁방치，피면감음신경성은력손실。
Objective To investigate radiation-induced sensorineural hearing loss in early nasopharyn-geal carcinoma. Methods Clinical data of patients with nasopharyngeal carcinoma treated by the authors from February 2006 to March 2012 were collected. Conventional pure tone audiometry test was conducted. DPOAE and bone conduction thresholds were recorded for frequencies of 0.5, 1, 2 and 4 kHz to compare hear-ing before and at 1.5 and 2 years after radiotherapy. Thresholds were examined separately for each frequency. Results Bone conduction thresholds before radiotherapy were lower than those at 1.5 and 2 years after radio-therapy. The differences were statistically significant for all frequencies (P<0.05). At 1.5 and 2 years after ra-diotherapy, DPOAE failing rate increased (P<0.05). Conclusion This study shows that the bone conduction threshold increases significantly in patients with early stage nasopharyngeal carcinoma treated with radiothera-py. All measures of prevention and treatment should be considered as early as possible in patients with naso-pharyngeal carcinoma who are receiving radiotherapy to prevent advance of sensorineural hearing loss.