CAJ | 학술논문

目的：回顾分析2014年1月—12月皮肤科门诊进行的560例皮肤炎性疾病患者光斑贴试验结果，探讨接触性变应原和光接触性变应原在一些皮肤炎性疾病中的作用。方法：收集接受光斑贴试验检测的皮肤炎性疾病患者患者560例，根据国际接触性皮炎研究组（International Contact Dermatitis Research Group ，ICDRG）的标准判读光斑贴试验结果，比较20种变应原的光接触性皮炎（photoallergic contact dermatitis ，PACD）及接触性皮炎（allergic contact dermatitis ，ACD）的阳性率。结果：560例患者中，PACD阳性378例（65．17％），ACD阳性342例（58．97％），PACD和 ACD均阳性62例（10．69％）。PACD最常见的阳性变应原是氯丙嗪（56．81％）、硫柳汞（12．19％）、甲醛（7．89％），ACD最常见的阳性变应原是甲醛（22．04％）、重铬酸钾（21．14％）、氯丙嗪（14．70％）。PACD和ACD均阳性的变应原中最常见的是氯丙嗪（6．27％）、硫柳汞（2．33％）、硫酸镍（1．61％）。结论：光接触性变应原和接触性变应原可能与慢性光化性皮炎、面部皮炎、湿疹等炎症性皮肤病的发病有关。
목적：회고분석2014년1월—12월피부과문진진행적560례피부염성질병환자광반첩시험결과，탐토접촉성변응원화광접촉성변응원재일사피부염성질병중적작용。방법：수집접수광반첩시험검측적피부염성질병환자환자560례，근거국제접촉성피염연구조（International Contact Dermatitis Research Group ，ICDRG）적표준판독광반첩시험결과，비교20충변응원적광접촉성피염（photoallergic contact dermatitis ，PACD）급접촉성피염（allergic contact dermatitis ，ACD）적양성솔。결과：560례환자중，PACD양성378례（65．17％），ACD양성342례（58．97％），PACD화 ACD균양성62례（10．69％）。PACD최상견적양성변응원시록병진（56．81％）、류류홍（12．19％）、갑철（7．89％），ACD최상견적양성변응원시갑철（22．04％）、중락산갑（21．14％）、록병진（14．70％）。PACD화ACD균양성적변응원중최상견적시록병진（6．27％）、류류홍（2．33％）、류산얼（1．61％）。결론：광접촉성변응원화접촉성변응원가능여만성광화성피염、면부피염、습진등염증성피부병적발병유관。
Objective:To explore the roles of contact allergens and photoallergens in the treatment of several inflammatory skin diseases by retrospectively analyzing the photopatch testing results of 560 patients from the Dermatology Department during January 2014 and December 2014 .Methods:A total of 560 patients undergoting photopatch testing were collected .The positive rates of photoallergic contact dermatitis(PACD) ,as well as those of allergic contact dermatitis(ACD) among the 20 types of allergens were compared by evaluating the photopatch testing results based on criteria from the International Contact Dermatitis Research Group (ICDRG) .Results:Among the 560 patients ,there were 378 cases (65 .17% ) with PACD positive , 342 cases (58 .97% ) with ACD positive ,and 62 cases (10 .69% ) with both PACD‐ and ACD‐positive .The most common allergens among PACD‐positive patients were chlorpromazine (56 .81% ) ,thiomersal (12 .19% ) ,and formaldehyde (7 .89% ) , whereas the most common allergens among ACD‐positive patients were formaldehyde (22 .04% ) , potassium dichromate (21 .14% ) , and chlorpromazine (14 .70% ) . Furthermore , the most common allergens among PACD‐ and ACD‐ positive patients were chlorpromazine (6 .27% ) ,thiomersal (2 .33% ) ,and nickel sulfate (1 .61% ) .Conclusions:Photoallergens and contact allergens may be related to the pathogenesis of inflammatory skin diseases such as chronic actinic dermatitis ,facial dermatitis ,and eczema .