中国临床医学
中國臨床醫學
중국림상의학
Chinese Journal of Clinical Medicine
2015年
5期
647-649
,共3页
低位直肠癌%局部切除术%放疗%排尿功能%肿瘤标志物
低位直腸癌%跼部切除術%放療%排尿功能%腫瘤標誌物
저위직장암%국부절제술%방료%배뇨공능%종류표지물
Low rectal cancer%Local resection%Radiotherapy%Urinary function%Tumor markers
目的：探讨早期低位直肠癌局部切除术后辅助放疗的安全性及其对患者血清CA199（carbohydrate antigen 199）表达、排尿功能及生存期的影响。方法：选择早期低位直肠癌患者120例。根据随机数字表法，将其分为治疗组和对照组，每组60例。两组均给予低位直肠癌局部切除术。治疗组术后进行放疗，疗程为5周。结果：两组治疗期间的不良反应以骨髓抑制、胃肠道反应、神经毒性为主，组间差异无统计学意义。两组治疗后的血清CA199浓度均明显低于治疗前（P＜0．05），治疗组治疗后血清CA199浓度明显低于对照组（P＜0．05）；治疗组治疗后的排尿功能明显优于对照组（P＜0．05）。所有患者随访至2015年7月，治疗组的中位生存期[（27．63±2．13）个月]与中位无进展生存期[（21．23±1．98）个月]均明显高于对照组[分别为（21．94±2．89）个月、（18．81±2．11）个月]，差异均有统计学意义（ P＜0．05）。结论：早期低位直肠癌局部切除术后辅助放疗的安全性较好，能降低血清CA199的表达水平、促进排尿功能的恢复及延长患者的生存时间。
目的：探討早期低位直腸癌跼部切除術後輔助放療的安全性及其對患者血清CA199（carbohydrate antigen 199）錶達、排尿功能及生存期的影響。方法：選擇早期低位直腸癌患者120例。根據隨機數字錶法，將其分為治療組和對照組，每組60例。兩組均給予低位直腸癌跼部切除術。治療組術後進行放療，療程為5週。結果：兩組治療期間的不良反應以骨髓抑製、胃腸道反應、神經毒性為主，組間差異無統計學意義。兩組治療後的血清CA199濃度均明顯低于治療前（P＜0．05），治療組治療後血清CA199濃度明顯低于對照組（P＜0．05）；治療組治療後的排尿功能明顯優于對照組（P＜0．05）。所有患者隨訪至2015年7月，治療組的中位生存期[（27．63±2．13）箇月]與中位無進展生存期[（21．23±1．98）箇月]均明顯高于對照組[分彆為（21．94±2．89）箇月、（18．81±2．11）箇月]，差異均有統計學意義（ P＜0．05）。結論：早期低位直腸癌跼部切除術後輔助放療的安全性較好，能降低血清CA199的錶達水平、促進排尿功能的恢複及延長患者的生存時間。
목적：탐토조기저위직장암국부절제술후보조방료적안전성급기대환자혈청CA199（carbohydrate antigen 199）표체、배뇨공능급생존기적영향。방법：선택조기저위직장암환자120례。근거수궤수자표법，장기분위치료조화대조조，매조60례。량조균급여저위직장암국부절제술。치료조술후진행방료，료정위5주。결과：량조치료기간적불량반응이골수억제、위장도반응、신경독성위주，조간차이무통계학의의。량조치료후적혈청CA199농도균명현저우치료전（P＜0．05），치료조치료후혈청CA199농도명현저우대조조（P＜0．05）；치료조치료후적배뇨공능명현우우대조조（P＜0．05）。소유환자수방지2015년7월，치료조적중위생존기[（27．63±2．13）개월]여중위무진전생존기[（21．23±1．98）개월]균명현고우대조조[분별위（21．94±2．89）개월、（18．81±2．11）개월]，차이균유통계학의의（ P＜0．05）。결론：조기저위직장암국부절제술후보조방료적안전성교호，능강저혈청CA199적표체수평、촉진배뇨공능적회복급연장환자적생존시간。
Objective:To investigate the safety of adjuvant radiotherapy following local resection for early stage low rectal cancer and its effect on patients’ serum CA199 expression ,urinary function ,and survival time .Methods:A total of 120 patients with early stage low rectal cancer were enrolled .By random number table method ,they were divided into the treatment group and the control group ,with 60 patients in each group .Local resection was given for low rectal cancer in two groups . Postoperative radiotherapy was conducted in the treatment group for a period of five weeks . Results: The main adverse reactions in two groups during the treatment were bone marrow suppression ,gastrointestinal reactions ,neurotoxicity ,and there was no statistically significant difference between the two groups .The serum CA199 expression in both groups after treatment was significantly lower than that before treatment (P< 0 .05) .The expression of serum CA199 in the treatment group after treatment was also significantly lower than that in the control group (P< 0 .05) .The urinary function in the treatment group after treatment was significantly superior to that in the control group ,and the difference was statistically significant (P<0 .05) .All patients were followed up till July 2015 .The median survival time [(27 .63 ± 2 .13) months] and the median progression‐free survival [(21 .23 ± 1 .98) months] in the treatment group were significantly higher than those in the control group [(21 .94 ± 2 .89) months and (18 .81 ± 2 .11) months] ,and the differences were statistically significant (P<0 .05) .Conclusions:The adjuvant radiotherapy following local resection is safe for the early stage low rectal cancer .It can reduce the serum CA199 expression ,promote the recovery of urinary function and prolong the survival time of patients .
