器官移植
器官移植
기관이식
Organ Transplantation
2015年
6期
415-419
,共5页
张竞文%陆英%李旭东
張競文%陸英%李旭東
장경문%륙영%리욱동
白血病,急性%儿童%高危%脐血移植%植入失败%脐血输注
白血病,急性%兒童%高危%臍血移植%植入失敗%臍血輸註
백혈병,급성%인동%고위%제혈이식%식입실패%제혈수주
Leukemia,acute%Child%High-risk%Cord blood transplantation%Transplantation failure%Cord blood infusion
目的：分析儿童高危急性淋巴细胞白血病脐血移植失败后白血病长期缓解的原因。方法收集2013年9月在中山大学附属第三医院血液内科接受脐血干细胞移植的1例高危急性淋巴细胞白血病患儿的临床资料。分析患儿术后治疗过程及预后，并结合文献资料分析患者移植失败但白血病治疗获得良好效果的可能原因。结果患儿首次脐血干细胞移植后造血恢复不良，2013年11月行脐血输注，后因为经济原因未针对原发病进一步治疗，然而该患者脐血移植术后15个月造血功能恢复，至2015年9月，脐血移植后2年无病生存。结论脐血移植或输注可能具有修复造血及免疫系统的功能，且无需通过成功植入发挥作用。儿童高危白血病进行脐血移植植入失败并不意味白血病治疗失败，患儿有可能获得长期无病生存。
目的：分析兒童高危急性淋巴細胞白血病臍血移植失敗後白血病長期緩解的原因。方法收集2013年9月在中山大學附屬第三醫院血液內科接受臍血榦細胞移植的1例高危急性淋巴細胞白血病患兒的臨床資料。分析患兒術後治療過程及預後，併結閤文獻資料分析患者移植失敗但白血病治療穫得良好效果的可能原因。結果患兒首次臍血榦細胞移植後造血恢複不良，2013年11月行臍血輸註，後因為經濟原因未針對原髮病進一步治療，然而該患者臍血移植術後15箇月造血功能恢複，至2015年9月，臍血移植後2年無病生存。結論臍血移植或輸註可能具有脩複造血及免疫繫統的功能，且無需通過成功植入髮揮作用。兒童高危白血病進行臍血移植植入失敗併不意味白血病治療失敗，患兒有可能穫得長期無病生存。
목적：분석인동고위급성림파세포백혈병제혈이식실패후백혈병장기완해적원인。방법수집2013년9월재중산대학부속제삼의원혈액내과접수제혈간세포이식적1례고위급성림파세포백혈병환인적림상자료。분석환인술후치료과정급예후，병결합문헌자료분석환자이식실패단백혈병치료획득량호효과적가능원인。결과환인수차제혈간세포이식후조혈회복불량，2013년11월행제혈수주，후인위경제원인미침대원발병진일보치료，연이해환자제혈이식술후15개월조혈공능회복，지2015년9월，제혈이식후2년무병생존。결론제혈이식혹수주가능구유수복조혈급면역계통적공능，차무수통과성공식입발휘작용。인동고위백혈병진행제혈이식식입실패병불의미백혈병치료실패，환인유가능획득장기무병생존。
Objective To analyze the reasons for long-term remission of leukemia after failure of cord blood stem cell transplantation for high-risk childhood acute lymphoblastic leukemia.Methods Clinical data of 1 child with high-risk acute lymphoblastic leukemia undergoing cord blood stem cell transplantation in the Department of Hematology of the Third Affiliated Hospital of Sun Yat-sen University in September 201 3 were collected.The treatment course and prognosis of the child were analyzed.In combination with literatures,the possible reasons for the good treatment effect on leukemia after transplantation failure were analyzed.Results The hematopoietic recovery of the child after the first cord blood stem cell transplantation was poor.The child underwent cord blood infusion in November 201 3 and did not undergo further treatment for the primary disease due to economic reasons. However, the hematopoietic function recovered 1 5 months after cord blood transplantation.Till September 201 5,2-year disease free survival after cord blood transplantation was obtained.Conclusions Cord blood transplantation or infusion may repair the function of hematopoietic system and immune system,and may take effect with no need of successful transplantation.The failure of cord blood transplantation for childhood high-risk leukemia does not mean treatment failure.Children patients may obtain long-term disease free survival.
