CAJ | 학술논문

目的：评价外涂大风子膏治疗成人慢性湿疹的临床疗效及其安全性。方法：将2013年1月—2015年3月收治的122例成人慢性湿疹患者随机分为治疗组（n＝60）和对照组（n＝62）。2组均在内服中药方剂的基础上外涂药膏，治疗组外涂大风子膏，对照组外涂冰黄肤乐软膏，2次／d，连续使用4周为1个疗程。观察、记录2组患者治疗1个疗程前后的各症状积分及不良反应，评价外用药物的临床疗效及安全性。结果：治疗组总有效率与对照组比较差异无统计学意义。对2组患者各症状积分进行逐项统计分析后显示，治疗组在减轻瘙痒、改善局部皮肤粗糙、角化、脱屑、浸润、苔藓样变等皮损形态以及提高睡眠质量方面优于对照组（P＜0．05）。治疗期间2组患者均未发生局部及全身不良反应。结论：外涂大风子膏治疗成人慢性湿疹疗效肯定，安全可靠，值得临床推广应用。
목적：평개외도대풍자고치료성인만성습진적림상료효급기안전성。방법：장2013년1월—2015년3월수치적122례성인만성습진환자수궤분위치료조（n＝60）화대조조（n＝62）。2조균재내복중약방제적기출상외도약고，치료조외도대풍자고，대조조외도빙황부악연고，2차／d，련속사용4주위1개료정。관찰、기록2조환자치료1개료정전후적각증상적분급불량반응，평개외용약물적림상료효급안전성。결과：치료조총유효솔여대조조비교차이무통계학의의。대2조환자각증상적분진행축항통계분석후현시，치료조재감경소양、개선국부피부조조、각화、탈설、침윤、태선양변등피손형태이급제고수면질량방면우우대조조（P＜0．05）。치료기간2조환자균미발생국부급전신불량반응。결론：외도대풍자고치료성인만성습진료효긍정，안전가고，치득림상추엄응용。
Objective:To evaluate the clinical efficacy and safety of external application of Dafengziointment in the treatment of adult chronic eczema .Methods:A total of 122 patients with adult chronic eczema ,admitted during Jan .2013 and Mar . 2015 ,were randomly divided into the treatment group (n= 60) and the control group(n= 62) .Both two groups received external application of ointment based on the oral formula of traditional Chinese medicine .The treatment group was given external application of Dafengzi ointment (twice daily ) , while the control group was given external application of Binghuang f ule ointment (twice daily) .And one course of treatment included 4 weeks of continuous application .The patients’ symptom integral and adverse reaction in two groups before and after one course of treatment were observed and recorded ,and the clinical curative effect and safety of the medication for external use was evaluated .Results: There was no significant difference regarding the total effective rate between the treatment group and the control group .The statistical analysis on each symptom integral for patients in two groups showed that ,the treatment group was superior to the control group on relieving pruritus and other local lesions such as rough ,cornification ,desquamation ,and lichenification ,as well as improving sleep quality (P<0 .05) .There was no local or systemic adverse reactions in both two groups during the treatment .Conclusions:The curative effect of external application of Dafengzi ointment in the treatment of adult chronic eczema is certain ,and it is safe and reliable .Thus ,it is worthy of clinical popularization .