CAJ | 학술논문

依据血液流动黏性不可压缩Navier-StoKes方程，建立了具有局部栓塞的分叉动脉有限元模型，模拟了栓塞率为0.25，0.5和0.75时分叉动脉内非牛顿血液的流场分布。在不同栓塞率下，研究了血液流速、血管壁面切应力和壁面压力对非牛顿血液流场分布的影响。结果表明，栓塞率较小时，分叉动脉内血液流动分离小，动脉栓塞对血流分布的影响较小；随着栓塞率增大，分叉动脉的分支处和栓塞处血液流动不稳定增强，分支左侧（Ⅰ）和栓塞后侧（Ⅱ）附近的血流停滞区面积逐渐增大，该处血管壁面切应力与壁面压力变化量急剧增大，血管内皮细胞易疲劳损伤，从而促进动脉粥样硬化的形成。数值模拟结果与临床病例分析一致，研究结果为临床上预防与治疗动脉粥样硬化疾病提供参考。
의거혈액류동점성불가압축Navier-StoKes방정，건립료구유국부전새적분차동맥유한원모형，모의료전새솔위0.25，0.5화0.75시분차동맥내비우돈혈액적류장분포。재불동전새솔하，연구료혈액류속、혈관벽면절응력화벽면압력대비우돈혈액류장분포적영향。결과표명，전새솔교소시，분차동맥내혈액류동분리소，동맥전새대혈류분포적영향교소；수착전새솔증대，분차동맥적분지처화전새처혈액류동불은정증강，분지좌측（Ⅰ）화전새후측（Ⅱ）부근적혈류정체구면적축점증대，해처혈관벽면절응력여벽면압력변화량급극증대，혈관내피세포역피로손상，종이촉진동맥죽양경화적형성。수치모의결과여림상병례분석일치，연구결과위림상상예방여치료동맥죽양경화질병제공삼고。
According to the Navier-StoKes equation of blood flow,the Kinetic model of the bifurcation artery was established and the non-Newtonian blood flowing was simulated in the rate of embolization 0 . 25 ,0 . 5 and 0 . 75 in bifurcation artery by using the method of computational fluid dynamics. The effect of different rate of embolozation in bifurcation artery to the non-Newtonian blood flowing from the velocity of blood flowing,wall shear stress and wall pressure was researched. The results showed that the blood flow separation was small and the influence of the distri-bution of blood flow was little in the initial stage of arterial embolization. With the rate of embolization increasing, the blood flow instability was enhancing,smaller blood stagnation area was increasing gradually,the vascular wall pressure and wall shear stress were changing quantity large in the left of branch and near embolism of arterial,vas-cular endothelial cells damaging for fatigue,and eventually leading to the formation of arterial thrombosis. The nu-merical simulation results consistent with the clinical cases,and the research results can also provide the theoretical reference for prevention and treatment the atherosclerotic disease in clinical.