CAJ | 학술논문

目的：研究黄连治疗糖尿病的物质基础。方法考察了黄连生物碱(小檗碱、黄连碱、巴马汀、表小檗碱和药根碱)对自发性糖尿病小鼠KK-Ay的降糖活性。结果连续给予生物碱(225 mg·kg-1·d-1,灌胃)40 d后,小檗碱和黄连碱能明显降低小鼠空腹血糖值并改善糖耐量；表小檗碱控制体重增长作用最强；小檗碱减缓了胰岛素( INS )抵抗；药根碱明显提高肝脏超氧化物歧化酶( SOD)含量,降低丙二醛( MDA)水平。结论黄连生物碱中起降糖作用的主要是小檗碱和黄连碱,巴马汀、表小檗碱和药根碱在治疗糖尿病方面发挥不同的协同作用。推测生物碱母核中A环C2、C3位的亚甲二氧基和D环C9、C10位的甲氧基同时存在时,降糖作用最强。
목적：연구황련치료당뇨병적물질기출。방법고찰료황련생물감(소벽감、황련감、파마정、표소벽감화약근감)대자발성당뇨병소서KK-Ay적강당활성。결과련속급여생물감(225 mg·kg-1·d-1,관위)40 d후,소벽감화황련감능명현강저소서공복혈당치병개선당내량；표소벽감공제체중증장작용최강；소벽감감완료이도소( INS )저항；약근감명현제고간장초양화물기화매( SOD)함량,강저병이철( MDA)수평。결론황련생물감중기강당작용적주요시소벽감화황련감,파마정、표소벽감화약근감재치료당뇨병방면발휘불동적협동작용。추측생물감모핵중A배C2、C3위적아갑이양기화D배C9、C10위적갑양기동시존재시,강당작용최강。
Aim To find the material foundation of treatment for diabetes in Coptidis Rhizoma ( RC ) . Methods The antihyperglycemic effect of RC alka-loids ( berberine, coptisine, palmatine, epiberberine, and jatrorrhizine) was evaluated in spontaneity diabe-tes KK-Ay mice. Results After 40 days′ oral admin-istration ( 225 mg · kg-1 · d-1 , ig ) , berberine and coptisine significantly suppressed the elevated fasting blood glucose level and ameliorated the glucose toler-ance . Body weight gain of KK-Ay mice was significant-ly decreased in the epiberberine-treated group. Berber-ine improved insulin resistance and jatrorrhizine in-creased the SOD activity, decreased the MDA level. Conclusions These results indicate that the main an-tihypoglycemic effect constituents are berberine and coptisine, while they show different mechanisms. Pal-matine, epiberberine and jatrorrhizine display different potential roles in the treatment of diabetes. The meth-ylene-dioxy groups at the C-2 , C-3 , C-9 and C-10 po-sitions are indispensable for antihyperglycemic effect of RC alkaloids.