CAJ | 학술논문

肿瘤转移是恶性肿瘤最为重要的生物学特征之一,同时也是影响预后及导致治疗失败的主要因素。近年来研究表明,肿瘤微环境中的胞外基质( extracellular matrix, ECM)纤维生成在肿瘤转移过程中发挥极为关键的作用。肿瘤ECM纤维生成会形成相互交联的网状结构,这种网状结构不仅对肿瘤细胞起到支持和营养作用,同时对肿瘤的生长和浸润也起到相当重要的作用。因此,阻断肿瘤组织ECM纤维生成有可能对肿瘤转移产生抑制作用,这使得ECM纤维生成作为治疗靶标,备受人们关注。该文对肿瘤ECM纤维生成与肿瘤转移研究进展进行综述,并对靶向肿瘤ECM纤维生成进行肿瘤转移治疗的策略进行探讨,为后续研究及指导临床提供重要参考。
종류전이시악성종류최위중요적생물학특정지일,동시야시영향예후급도치치료실패적주요인소。근년래연구표명,종류미배경중적포외기질( extracellular matrix, ECM)섬유생성재종류전이과정중발휘겁위관건적작용。종류ECM섬유생성회형성상호교련적망상결구,저충망상결구불부대종류세포기도지지화영양작용,동시대종류적생장화침윤야기도상당중요적작용。인차,조단종류조직ECM섬유생성유가능대종류전이산생억제작용,저사득ECM섬유생성작위치료파표,비수인문관주。해문대종류ECM섬유생성여종류전이연구진전진행종술,병대파향종류ECM섬유생성진행종류전이치료적책략진행탐토,위후속연구급지도림상제공중요삼고。
Tumor metastasis is one of the most important biologi-cal characteristics of malignant tumor, and it is also the main factor resulting in poor prognosis and leading to failure of treat-ment. In recent years, studies have shown that the extracellular matrix ( ECM) of tumor microenvironment plays a critical role in tumor metastasis. Tumor ECM fibrogenesis could form the cross-linked network structure, which not only provides nutrition and support to tumor, also it is necessary to tumor growth and inva-sion. These research results indicate that blocking ECM fibro-genesis may exert an inhibitory effect on tumor metastasis. Therefore, targeting ECM fibrogenesis has become a particularly attractive strategy as it can be used in the treatment of metasta-sis-related diseases. The ECM fibrogenesis in tumor is reviewed in this paper as well as the treatment strategies on tumor metas-tasis by targeting ECM fibrogenesis, which may provide refer-ences for follow-up research and clinical treatment.